ArticleInternational journal of experimental pathology2008
Down-regulation of MyoD gene expression in rat diaphragm muscle with heart failure.
Article in International journal of experimental pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Preventive training does not interfere with mRNA-encoding myosin and collagen expression during pulmonary arterial hypertension.PloS one · 2021Article
- Article
- Article
- Fractal Dimension in Quantifying Experimental-Pulmonary-Hypertension-Induced Cardiac Dysfunction in Rats.Arquivos brasileiros de cardiologia · 2016Article
- Preventive aerobic training exerts a cardioprotective effect on rats treated with monocrotaline.International journal of experimental pathology · 2016Article
- Skeletal Muscle Changes in Chronic Cardiac Disease and Failure.Comprehensive Physiology · 2015Review
- Myogenin gene expression is not altered in the developing diaphragm of nitrofen-induced congenital diaphragmatic hernia.Pediatric surgery international · 2014Article
- Morphological aspects of neuromuscular junctions and gene expression of nicotinic acetylcholine receptors (nAChRs) in skeletal muscle of rats with heart failure.Journal of molecular histology · 2011Article
- Differential morphofunctional characteristics and gene expression in fast and slow muscle of rats with monocrotaline-induced heart failure.Journal of molecular histology · 2011Article
- Myostatin and follistatin expression in skeletal muscles of rats with chronic heart failure.International journal of experimental pathology · 2010Article
- Respiratory muscle function and exercise intolerance in heart failure.Current heart failure reports · 2009Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diaphragm myopathy has been described in patients with heart failure (HF), with alterations in myosin heavy chains (MHC) expression. The pathways that regulate MHC expression during HF have not been described, and myogenic regulatory factors (MRFs) may be involved. The purpose of this investigation was to determine MRF mRNA expression levels in the diaphragm. Diaphragm muscle from both HF and control Wistar rats was studied when overt HF had developed, 22 days after monocrotaline administration. MyoD, myogenin and MRF4 gene expression were determined by RT-PCR and MHC isoforms by polyacrylamide gel electrophoresis. Heart failure animals presented decreased MHC IIa/IIx protein isoform and MyoD gene expression, without altering MHC I, IIb, myogenin and MRF4. Our results show that in HF, MyoD is selectively down-regulated, which might be associated with alterations in MHC IIa/IIx content. These changes are likely to contribute to the diaphragm myopathy caused by HF.
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Registered trials
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