ArticleAnnals of human genetics2008
Genetic epidemiology of subclinical cardiovascular disease in the diabetes heart study.
Article in Annals of human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Pooled it
- Traditional cardiovascular risk factors explain the minority of the variability in carotid plaque.Stroke · 2012Trial
- Association ofJournal of cardiovascular development and disease · 2024Article
- Heart rate is an independent predictor of all-cause mortality in individuals with type 2 diabetes: The diabetes heart study.World journal of diabetes · 2018Article
- Article
- Prevalence and Risk Factors of Carotid Plaque Among Middle-aged and Elderly Adults in Rural Tianjin, China.Scientific reports · 2016Article
- Analysis of advanced glycation end products in the DHS Mind Study.Journal of diabetes and its complications · 2016Article
- Relationships between Cognitive Performance, Neuroimaging and Vascular Disease: The DHS-MIND Study.Neuroepidemiology · 2015Article
- Prediction of mortality using a multi-bed vascular calcification score in the Diabetes Heart Study.Cardiovascular diabetology · 2014Article
- Contributors to mortality in high-risk diabetic patients in the Diabetes Heart Study.Diabetes care · 2014Article
- Heritability and genetic association analysis of cognition in the Diabetes Heart Study.Neurobiology of aging · 2014Article
- Analysis of common and coding variants with cardiovascular disease in the Diabetes Heart Study.Cardiovascular diabetology · 2014Article
- Genetic risk score associations with cardiovascular disease and mortality in the Diabetes Heart Study.Diabetes care · 2014Article
- Diabetes: Unravelling the enigma of T2DM and cardiovascular disease.Nature reviews. Endocrinology · 2013Article
- Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.Atherosclerosis · 2013Article
- Polymorphisms in the Selenoprotein S gene and subclinical cardiovascular disease in the Diabetes Heart Study.Acta diabetologica · 2013Article
- Glomerular filtration rate and albuminuria predict mortality independently from coronary artery calcified plaque in the Diabetes Heart Study.Cardiovascular diabetology · 2013Article
- Usefulness of biventricular volume as a predictor of mortality in patients with diabetes mellitus (from the Diabetes Heart Study).The American journal of cardiology · 2013Article
- Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the Diabetes Heart Study.Cardiovascular diabetology · 2013Article
- C-reactive protein concentration predicts mortality in type 2 diabetes: the Diabetes Heart Study.Diabetic medicine : a journal of the British Diabetic Association · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
A genome-wide linkage scan of 357 European American (EA) and 72 African American (AA) pedigrees multiplex for type 2 diabetes mellitus (T2DM) was performed with multipoint nonparametric QTL linkage analysis. Four subclinical measures of cardiovascular disease (CVD): coronary artery (CCP), carotid artery (CarCP), and abdominal aortic calcified plaque (AACP) and carotid artery intima-media thickness (IMT) were mapped. Analyses were adjusted for age, gender, body mass index, and (if appropriate) ethnicity and diabetes status. Evidence for linkage was observed in EA T2DM subjects to CarCP near 16p13 (LOD=4.39 at 8.4 cM; P = 0.00001). When all EA subjects were included, the LOD score was 2.52, suggesting an amplification of the linkage by diabetes. Linkage analysis of a principal components measure of vascular calcium (LOD = 3.85 at 9.3 cM on 16p in EA T2DM subjects) and bivariate analysis of CarCP X IMT (LOD = 3.77 at 9.3 cM on 16p in EA T2DM subjects) were consistent with this linkage. In addition, evidence for linkage was observed with CCP near D15S1515 (LOD = 2.34) in EAs. Additional loci on chromosomes 1, 2, 7, 10, 13, and 21 had LODs > 2.0. The identification of trait-determining polymorphisms underlying these linkages will help delineate risk factors for CVD in T2DM and the general population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.