ArticleMolecular biology reports2009
A common variant on chromosome 9p21 affects the risk of early-onset coronary artery disease.
Article in Molecular biology reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis.International journal of molecular sciences · 2014Pooled it
- The association of 9p21-3 locus with coronary atherosclerosis: a systematic review and meta-analysis.BMC medical genetics · 2014Pooled it
- Association between 9p21.3 genomic markers and coronary artery disease in East Asians: a meta-analysis involving 9,813 cases and 10,710 controls.Molecular biology reports · 2013Pooled it
- Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease.Circulation. Cardiovascular genetics · 2010Pooled it
- The 9p21 susceptibility locus for coronary artery disease and the severity of coronary atherosclerosis.BMC cardiovascular disorders · 2009Trial
- Polymorphism rs2383207 of CDKN2B-AS and Susceptibility to Atherosclerosis: A Mini Review.Non-coding RNA · 2022Review
- The Senescence Markers p16INK4A, p14ARF/p19ARF, and p21 in Organ Development and Homeostasis.Cells · 2022Review
- Genetic and epigenetic associations of ANRIL with coronary artery disease and risk factors.BMC medical genomics · 2021Article
- Influence of rs1746048 SNPs on clinical manifestations and incidence of acute myocardial infarction in Guangxi Han population.International journal of clinical and experimental pathology · 2019Article
- The assessment of the relationship between variations in the apelin gene and coronary artery disease in Turkish population.Anatolian journal of cardiology · 2015Observational
- The cardiovascular implication of single nucleotide polymorphisms of chromosome 9p21 locus among Arab population.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Article
- Evaluation of association between common genetic variants on chromosome 9p21 and coronary artery disease in Turkish population.Anatolian journal of cardiology · 2015Article
- Article
- Polymorphism on Chromosome 9p21.3 Is Associated with Severity and Early-Onset CAD in Type 2 Diabetic Tunisian Population.Disease markers · 2015Article
- The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey).International journal of endocrinology · 2015Article
- A novel polymorphism (901G > a) of C5L2 gene is associated with coronary artery disease in Chinese Han and Uyghur population.Lipids in health and disease · 2013Article
- A novel major histocompatibility complex locus confers the risk of premature coronary artery disease in a Chinese Han population.Molecular biology reports · 2013Article
- Association of two variants in the interleukin-6 receptor gene and premature coronary heart disease in a Chinese Han population.Molecular biology reports · 2013Article
- Clinical utility of novel biomarkers for cardiovascular disease risk stratification.Internal and emergency medicine · 2012Review
- Genetics of coronary artery disease in the 21st century.Clinical cardiology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Two single nucleotide polymorphisms (SNPs, rs10757278 and rs2383207) on chromosome 9p21 have been proved to be associated with myocardial infarction. We investigated whether these two genetic markers are determinants of early-onset coronary artery disease. Methods and results A total of 444 consecutive patients were studied including 212 cases with coronary stenosis >or=50% or previous myocardial infarction and 232 controls without documented coronary artery disease. Ligase detection reaction was performed to detect two SNPs. After adjustment of clinical parameters, significant associations were identified for the rs2383207 and rs10757278 SNPs, with A/G and G/G genetypes at rs10757278 and G/G genetype carriers at rs2383207 having a higher risk of early-onset coronary artery disease than carriers of A/A genotype (odds ratio [OR] 2.207, 95% CI: 1.069-4.394, P = 0.028; OR 3.051, 95% CI: 1.086-8.567, P = 0.004; OR 2.964, 95% CI: 1.063-8.265, P = 0.038, respectively). There were no associations between rs10757278 and rs2383207 genotypes and the severity of coronary artery disease (both P > 0.05). Conclusions The rs10757278 and rs2383207 variants are determinants for early-onset coronary artery disease. These markers may help the identification of patients at increased risk for early-onset coronary artery disease.
Indexed as
Identifiers
18459066What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.