ArticlePediatric nephrology (Berlin, Germany)2008
Flow-mediated vasodilatation of the brachial artery in children with chronic kidney disease.
Article in Pediatric nephrology (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Effects of L-Citrulline Supplementation and Aerobic Training on Vascular Function in Individuals with Obesity across the Lifespan.Nutrients · 2021Review
- Oxidative stress in chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2019Review
- Hypertension in chronic kidney disease: role of ambulatory blood pressure monitoring.Progress in pediatric cardiology · 2016Article
- Effect of cholecalciferol on local arterial stiffness and endothelial dysfunction in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2016Article
- Brachial artery flow-mediated dilatation and carotid intima medial thickness in pediatric nephrotic syndrome: a cross-sectional case-control study.Clinical and experimental nephrology · 2015Article
- Peripheral vascular dysfunction in chronic kidney disease.Cardiology research and practice · 2011Article
- Cardiovascular disease in CKD in children: update on risk factors, risk assessment, and management.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2009Review
- Cardiovascular disease in children with CKD or ESRD.Nature reviews. Nephrology · 2009Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We sought to determine flow-mediated vasodilatation (FMD) of the brachial artery and to assess the relationship of FMD with multiple demographic, clinical and biochemical parameters and cardiac and vascular structure and function in children with chronic kidney disease (CKD) stages 2-4. Forty-three patients, aged 6-20 years, with CKD [mean glomerular filtration rate (GFR) 47 +/- 21 ml/min per 1.73 m2 body surface area, range 16-89 ml/min per 1.73 m2] and 34 healthy age-matched controls were included and studied cross-sectionally between 2001 and 2005. The peak FMD was similar in the CKD and control subjects (mean 6.3% vs 6.7%, P = 0.85). However, abnormally low FMD (< 1.1%) was found in ten (23%) children with CKD. Among children with CKD, those with low FMD were younger, shorter, lighter, and had lower body mass index (BMI) than children with normal FMD, but the difference reached statistical significance only for weight and BMI. Serum triglyceride levels were significantly lower in those with low FMD; otherwise, the two groups were similar with respect to multiple clinical and biochemical parameters. Cardiac and vascular structure was similar in children with normal and low FMD. In conclusion, children with CKD stage 2-4 appear to have increased prevalence of decreased FMD of the brachial artery. However, our study identified few significant factors associated with low FMD in children with CKD.
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