ArticlePflugers Archiv : European journal of physiology2008
In situ recording from gut pacemaker cells.
Article in Pflugers Archiv : European journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Insights Into Gastrointestinal Motility Through the Use of Optogenetic Sensors.Journal of neurogastroenterology and motility · 2024Article
- Article
- Slow Wave Activity and Modulations in Mouse Jejunum Myenteric Plexus In Situ.Journal of neurogastroenterology and motility · 2017Article
- Ano1 is a better marker than c-Kit for transcript analysis of single interstitial cells of Cajal in culture.Cellular & molecular biology letters · 2014Article
- Cholinergic signalling-regulated KV7.5 currents are expressed in colonic ICC-IM but not ICC-MP.Pflugers Archiv : European journal of physiology · 2014Article
- Bacteroides fragilis polysaccharide A is necessary and sufficient for acute activation of intestinal sensory neurons.Nature communications · 2013Article
- Lucifer yellow - an angel rather than the devil.Journal of cellular and molecular medicine · 2012Review
- Biophysically based modeling of the interstitial cells of cajal: current status and future perspectives.Frontiers in physiology · 2011Article
- Multiscale modeling of gastrointestinal electrophysiology and experimental validation.Critical reviews in biomedical engineering · 2010Review
- Interstitial cells of Cajal in the gut: what makes them tick?The Journal of physiology · 2009Article
- Review article: gastric electrical stimulation for gastroparesis--physiological foundations, technical aspects and clinical implications.Alimentary pharmacology & therapeutics · 2009Review
- Cellular pathogenesis of diabetic gastroenteropathy.Minerva gastroenterologica e dietologica · 2009Review
- Voltage-dependent Ca Current Identified in Freshly Isolated Interstitial Cells of Cajal (ICC) of Guinea-pig Stomach.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interstitial cells of Cajal (ICC) associated with the myenteric plexus of the small intestine are crucial players in gut physiology performing pacemaker functions and directing peristalsis and segmentation. ICC have been studied after chemical isolation and under culture conditions, but concerns that these methods affect the intrinsic properties have hindered progress in our understanding of ICC. To overcome this problem, we have developed a method to obtain electrophysiological recordings from ICC in situ. The critical feature is the ability to make high resistance seals onto cells that are embedded within tissue to obtain patch clamp recordings. Our first results show a prominent presence of a chloride channel, one of the proposed ICC pacemaker channels. The developed method can be applied to auxiliary cells of the enteric nervous system such as glial cells or fibroblasts and will be ideal for the study of cell-cell communication in tissue.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.