ReviewEuropean journal of nutrition2008
Biomarkers of dietary intake of flavonoids and phenolic acids for studying diet-cancer relationship in humans.
Review in European journal of nutrition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Correlations between urinary concentrations and dietary intakes of flavonols in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.European journal of nutrition · 2020Article
- Adherence to the Saudi dietary guidelines and its relation to colorectal polyps: A university hospital-based study.Journal of Taibah University Medical Sciences · 2020Article
- Technology and Process Design for Phenols Recovery from Industrial Chicory (Molecules (Basel, Switzerland) · 2019Article
- The urinary phenolic acid profile varies between younger and older adults after a polyphenol-rich meal despite limited differences in in vitro colonic catabolism.European journal of nutrition · 2019Article
- Flavonoid intake from fruit and vegetables during adolescence is prospectively associated with a favourable risk factor profile for type 2 diabetes in early adulthood.European journal of nutrition · 2019Article
- Habitual Flavonoid Intake from Fruit and Vegetables during Adolescence and Serum Lipid Levels in Early Adulthood: A Prospective Analysis.Nutrients · 2018Article
- Article
- Relative validation of 24-h urinary hippuric acid excretion as a biomarker for dietary flavonoid intake from fruit and vegetables in healthy adolescents.European journal of nutrition · 2017Article
- Biomarkers of Dietary Polyphenols in Cancer Studies: Current Evidence and Beyond.Oxidative medicine and cellular longevity · 2015Review
- Measuring exposure to the polyphenol metabolome in observational epidemiologic studies: current tools and applications and their limits.The American journal of clinical nutrition · 2014Review
- High concentrations of a urinary biomarker of polyphenol intake are associated with decreased mortality in older adults.The Journal of nutrition · 2013Article
- Associations between flavonoids and cardiovascular disease incidence or mortality in European and US populations.Nutrition reviews · 2012Review
- Flavonoid intakes in the Baltimore Longitudinal Study of Aging.Journal of food composition and analysis : an official publication of the United Nations University, International Network of Food Data Systems · 2011Article
- Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples.Archives of toxicology · 2010Review
- Antioxidant mechanisms of Quercetin and Myricetin in the gas phase and in solution--a comparison and validation of semi-empirical methods.Journal of molecular modeling · 2010Article
- Introducing N-glycans into natural products through a chemoenzymatic approach.Carbohydrate research · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFor many polyphenolic compounds found in plant-derived food, biological effects possibly relevant for cancer prevention have been shown. Since dietary intake estimates suffer from imprecision, the measurement of these compounds (or metabolites of) in biological specimens collected in epidemiological studies is expected to improve accuracy of exposure estimation. AIM OF THE STUDY: The current use of biomarkers in etiologic studies on polyphenolics and cancer risk is evaluated. In addition, available analytical methods are discussed with respect to the requirements for their integration in epidemiological studies, putting specific emphasis on the epidemiological validation of such markers.
methodsThe scientific literature was screened for epidemiologic studies on the relationship of flavonoid and phenolic acid concentrations in human specimens (i.e. blood, urine) and cancer risk. In addition, original data on intra- and inter-subject variability of several flavonoids and phenolic acids are presented.
resultsAlthough several techniques are used in bioavailability or short-term intervention studies, their integration in epidemiological studies is very limited. An exception are phytoestrogens where validated immunoassays allow the rapid measurement of large sample numbers with small sample volume. For several polyphenols, the data on the epidemiologic validity encourages for their use in epidemiological studies.
conclusionsThere are valid possibilities for additional biomarkers of flavonoid and phenolic acid intake that are best applied in prospective studies with more than one biological sample per subject. Currently, a combination of a single biomarker measurement with long-term dietary intake estimates will probably be the most valuable choice to decrease measurement error in exposure data.
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Registered trials
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