ReviewEuropean journal of nutrition2008
Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker?
Review in European journal of nutrition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 71 citations in OpenAlex.
- Losartan abolishes oxidative stress induced by intermittent hypoxia in humans.The Journal of physiology · 2011Trial
- Micronutrient Food Supplements in Patients with Gastro-Intestinal and Hepatic Cancers.International journal of molecular sciences · 2021Review
- Biomarkers of nucleic acid oxidation - A summary state-of-the-art.Redox biology · 2021Article
- Impact of Physical Activity on Oxidative Stress Markers in Patients with Metastatic Breast Cancer.Oxidative medicine and cellular longevity · 2021Article
- Potential Protective Effect of Dietary Intake of Non-Oxidative medicine and cellular longevity · 2020Article
- Methanolic extract of Potentilla fulgens root and its ethyl-acetate fraction delays the process of carcinogenesis in mice.Scientific reports · 2019Article
- Potential biomarkers associated with oxidative stress for risk assessment of colorectal cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2017Review
- Cyclooxygenase-2 Inhibition Limits Angiotensin II-Induced DNA Oxidation and Protein Nitration in Humans.Frontiers in physiology · 2017Article
- Effects of exercise on markers of oxidative stress: an Ancillary analysis of the Alberta Physical Activity and Breast Cancer Prevention Trial.BMJ open sport & exercise medicine · 2016Article
- Age and metabolic risk factors associated with oxidatively damaged DNA in human peripheral blood mononuclear cells.Oncotarget · 2015Article
- Oxidized extracellular DNA as a stress signal in human cells.Oxidative medicine and cellular longevity · 2013Review
- Preparation, characterization and efficacy evaluation of synthetic biocompatible polymers linking natural antioxidants.Molecules (Basel, Switzerland) · 2012Article
- Tomato juice intake suppressed serum concentration of 8-oxodG after extensive physical activity.Nutrition journal · 2012Article
- Protection by flavanol-rich foods against vascular dysfunction and oxidative damage: 27th Hohenheim Consensus Conference.Advances in nutrition (Bethesda, Md.) · 2012Article
- Effects of a Rubus coreanus Miquel supplement on plasma antioxidant capacity in healthy Korean men.Nutrition research and practice · 2011Article
- 8-oxo-7,8-dihydro-2'-deoxyguanosine as a biomarker of oxidative damage in oesophageal cancer patients: lack of association with antioxidant vitamins and polymorphism of hOGG1 and GST.Journal of experimental & clinical cancer research : CR · 2010Article
- Beta-carotene is an important vitamin A source for humans.The Journal of nutrition · 2010Article
- Salvage of oxidized guanine derivatives in the (2'-deoxy)ribonucleotide pool as source of mutations in DNA.Mutation research · 2010Review
- Stable-isotope dilution LC–MS for quantitative biomarker analysis.Bioanalysis · 2010Review
- Use of supplements of multivitamins, vitamin C, and vitamin E in relation to mortality.American journal of epidemiology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative damage to DNA is regarded as an important step in carcinogenesis. These lesions may arise as a consequence of exposure to xenobiotics, but are also generated as a consequence of endogenous generation of oxidizing compounds. Measurements of oxidative damage to guanines, such as 8-oxo-7, 8-dihydroguanine (8-oxodG) are increasingly being regarded as reliable biomarkers of oxidative stress and they may have a predictive value of cancer risk, although this needs to be established independently in several cohort studies. A survey of intervention studies of the ingestion of antioxidant-containing foods or tablets of antioxidants indicate that about one-third of the studies reported a protective effect in terms of lower levels of oxidative damage to DNA in white blood cells or decreased urinary excretion of 8-oxodG. Although firm conclusions cannot be reached, there appears to be links between ingestion of antioxidants, oxidative damage to DNA, and risk of cancer.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.