ArticleJournal of neuro-oncology2008
(99m)Tc-Tetrofosmin brain SPECT in the assessment of meningiomas-correlation with histological grade and proliferation index.
Article in Journal of neuro-oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Characterization of intracranial space-occupying lesions by ⁹⁹(m)Tc-Tetrofosmin SPECT.Journal of neuro-oncology · 2011Trial
- Review
- Meningioma grading based on positron emission tomography: A systematic review and meta-analysis.World neurosurgery: X · 2023Article
- Magnetic Resonance Spectroscopy and Single-Photon Emission Computed Tomography in the Evaluation of Cerebral Tumors: A Case Report.Journal of clinical medicine research · 2017Article
- Progress on the diagnosis and evaluation of brain tumors.Cancer imaging : the official publication of the International Cancer Imaging Society · 2013Review
- SPECT and PET imaging of meningiomas.TheScientificWorldJournal · 2012Article
- Influence of glioma's multidrug resistance phenotype on (99m)Tc-tetrofosmin uptake.Molecular imaging and biology · 2011Article
- Update on meningiomas.The oncologist · 2011Review
- Glioma recurrence versus radiation necrosis: accuracy of current imaging modalities.Journal of neuro-oncology · 2009Review
- Technetium Tc99m-tetrofosmin brain single-photon emission CT for the diagnosis of malignant meningiomas.AJNR. American journal of neuroradiology · 2009Article
- 99mTc-tetrofosmin SPECT for glioma evaluation.Molecular imaging and biologyArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meningiomas account for about 30% of all intracranial tumors. Evaluation of their proliferation rate is useful for assessing their biological behavior. We evaluated prospectively whether (99m)Tc-Tetrofosmin ((99m)Tc-TF) uptake in meningiomas correlates with cellular proliferative activity and with tumor grade. We prospectively studied 18 meningioma cases. Brain single-photon emission computed tomography (SPECT) by (99m)Tc-TF was performed within a week prior to surgical excision. In the excised tumor specimens we assessed Ki-67 antigen expression. 14 of 18 patients had benign meningiomas, while the remaining four had anaplastic meningiomas. A significant correlation was found between both (99m)Tc-TF uptake and tumor grade (r = 0.722, P = 0.001) and between (99m)Tc-TF uptake and Ki-67 expression (r = 0.930, P < 0.001). There was a significant correlation between the intensity of tracer uptake and tumor recurrence at 1 year postoperative (r = 0.574, P = 0.02). This pilot study implies that (99m)Tc-TF brain SPECT could prove useful in differentiating benign from anaplastic meningiomas and is a potential indicator of their proliferative activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.