Evidence map›Paper›PMID 18458349›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2008

What's the point of the type III secretion system needle?

Ariel J Blocker, Janet E Deane, Andreas K J Veenendaal, Pietro Roversi, Julie L Hodgkinson, Steven Johnson, Susan M Lea

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed.

  1. Article
  2. Mechanistic blockade ofAntimicrobial agents and chemotherapy · 2025
    Article
  3. Article
  4. Type III Secretion inMicrobiology and molecular biology reviews : MMBR · 2023
    Review
  5. A ParDE toxin-antitoxin system is responsible for the maintenance of theFrontiers in cellular and infection microbiology · 2023
    Article
  6. Article
  7. Cryo-EM structure of the needle filament tip complex of theProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  8. Article
  9. TheMicroorganisms · 2021
    Review
  10. VscF in T3SS1 Helps to Translocate VPA0226 inFrontiers in cellular and infection microbiology · 2021
    Article
  11. High-resolution view of the type III secretion export apparatus in situ reveals membrane remodeling and a secretion pathway.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ariel J BlockerDepartment of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom.
Janet E Deane
Andreas K J Veenendaal
Pietro Roversi
Julie L Hodgkinson
Steven Johnson
Susan M Lea

Funding

Medical Research Council G0400389Medical Research Council G0400775Medical Research Council G0401595Wellcome Trust 077082
6 · The paper itself

Abstract

Recent work by several groups has significantly expanded our knowledge of the structure, regulation of assembly, and function of components of the extracellular portion of the type III secretion system (T3SS) of Gram-negative bacteria. This perspective presents a structure-informed analysis of functional data and discusses three nonmutually exclusive models of how a key aspect of T3SS biology, the sensing of host cells, may be performed.

Indexed as

Bacterial ProteinsBiosensing TechniquesModels, BiologicalModels, MolecularProtein Structure, QuaternaryShigellaBacterial Proteins

Identifiers

PMID18458349
PMCPMC2373345

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.