ArticleProceedings of the National Academy of Sciences of the United States of America2008
Tissue-engineered endothelial and epithelial implants differentially and synergistically regulate airway repair.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 64 citations in OpenAlex.
- CD45/CD11b positive subsets of adult lung anchorage-independent cells harness epithelial stem cells in culture.Journal of tissue engineering and regenerative medicine · 2013Trial
- Towards a bioengineered airway: advances in tracheal tissue engineering and biofabrication.Frontiers in cell and developmental biology · 2026Review
- An acoustic-optic confocal probe based photoacoustic and ultrasonic tracheal endoscopy for characterizing phantom and model of chronic obstructive pulmonary disease.Photoacoustics · 2025Article
- Autologous Airway Basal Cell Transplantation Alleviates Airway Epithelium Defect in Recurrent Benign Tracheal Stenosis.Stem cells translational medicine · 2023Article
- Gamma Irradiation Processing on 3D PCL Devices-A Preliminary Biocompatibility Assessment.International journal of molecular sciences · 2022Article
- Article
- Perpendicular implantation of porcine trachea extracellular matrix for enhanced xenogeneic scaffold surface epithelialization in a canine model.Frontiers in surgery · 2022Article
- CD34Heart and vessels · 2018Article
- 3D matrix-embedding inhibits cycloheximide-mediated sensitization to TNF-alpha-induced apoptosis of human endothelial cells.Journal of tissue engineering and regenerative medicine · 2018Article
- Article
- Tracheal Replacement Therapy with a Stem Cell-Seeded Graft: Lessons from Compassionate Use Application of a GMP-Compliant Tissue-Engineered Medicine.Stem cells translational medicine · 2017Article
- A novel endothelial-derived anti-inflammatory activity significantly inhibits spontaneous choroidal neovascularisation in a mouse model.Vascular cell · 2016Article
- Engineering functional epithelium for regenerative medicine and in vitro organ models: a review.Tissue engineering. Part B, Reviews · 2013Review
- Dysfunctional endothelial cells directly stimulate cancer inflammation and metastasis.International journal of cancer · 2013Article
- The evolution of endothelial regulatory paradigms in cancer biology and vascular repair.Cancer research · 2011Review
- Matrix-embedded endothelial cells are protected from the uremic milieu.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2011Article
- Stromal endothelial cells directly influence cancer progression.Science translational medicine · 2011Article
- Hybrid titanium/biodegradable polymer implants with an hierarchical pore structure as a means to control selective cell movement.PloS one · 2011Article
- Recent advances and new opportunities in lung mechanobiology.Journal of biomechanics · 2010Review
- Linking optics and mechanics in an in vivo model of airway fibrosis and epithelial injury.Journal of biomedical opticsArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The trilaminate vascular architecture provides biochemical regulation and mechanical integrity. Yet regulatory control can be regained after injury without recapitulating tertiary structure. Tissue-engineered (TE) endothelium controls repair even when placed in the perivascular space of injured vessels. It remains unclear from vascular repair studies whether endothelial implants recapitulate the vascular epithelial lining or expose injured tissues to endothelial cells (ECs) with unique healing potential because ECs line the vascular epithelium and the vasa vasorum. We examined this issue in a nonvascular tubular system, asking whether airway repair is controlled by bronchial epithelial cells (EPs) or by ECs of the perfusing bronchial vasculature. Localized bronchial denuding injury damaged epithelium, narrowed bronchial lumen, and led to mesenchymal cell hyperplasia, hypervascularity, and inflammatory cell infiltration. Peribronchial TE constructs embedded with EPs or ECs limited airway injury, although optimum repair was obtained when both cells were present in TE matrices. EC and EP expression of PGE(2), TGFbeta1, TGFbeta2, GM-CSF, IL-8, MCP-1, and soluble VCAM-1 and ICAM-1 was altered by matrix embedding, but expression was altered most significantly when both cells were present simultaneously. EPs may provide for functional control of organ injury and fibrous response, and ECs may provide for preservation of tissue perfusion and the epithelium in particular. Together the two cells optimize functional restoration and healing, suggesting that multiple cells of a tissue contribute to the differentiated biochemical function and repair of a tissue, but need not assume a fixed, ordered architectural relationship, as in intact tissues, to achieve these effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.