SynthesisNeurology2008
Assessment: Botulinum neurotoxin for the treatment of movement disorders (an evidence-based review) [RETIRED]: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.
Synthesis in Neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
148 citing papers in PubMed, 8 syntheses or guidelines pooled it, 617 citations in OpenAlex.
- Comparative efficacy and safety of botulinum neurotoxin type A in blepharospasm and hemifacial spasm: a systematic review and Bayesian network meta-analysis.Journal of neural transmission (Vienna, Austria : 1996) · 2026Pooled it
- Pooled it
- Pooled it
- Use of AbobotulinumtoxinA in Adults with Cervical Dystonia: A Systematic Literature Review.Toxins · 2020Pooled it
- Guideline
- A mixed treatment comparison to compare the efficacy and safety of botulinum toxin treatments for cervical dystonia.Journal of neurology · 2016Pooled it
- Efficacy and safety of long-term botulinum toxin treatment in craniocervical dystonia: a systematic review.Neurotoxicity research · 2012Pooled it
- Botulinum toxin injections for low-back pain and sciatica.The Cochrane database of systematic reviews · 2011Pooled it
- Trial
- Trial
- Trial
- [Molecular imaging and biology · 2020Trial
- Sensorimotor Perceptive Rehabilitation Integrated (SPRInt) program: exercises with augmented movement feedback associated to botulinum neurotoxin in idiopathic cervical dystonia-an observational study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Trial
- Personalized botulinum toxin type A therapy for cervical dystonia based on kinematic guidance.Journal of neurology · 2018Trial
- Assessing adverse effects of intra-articular botulinum toxin A in healthy Beagle dogs: A placebo-controlled, blinded, randomized trial.PloS one · 2018Trial
- Dysport and Botox at a ratio of 2.5:1 units in cervical dystonia: a double-blind, randomized study.Movement disorders : official journal of the Movement Disorder Society · 2015Trial
- Trial
- A randomized, double-blind study of repeated incobotulinumtoxinA (Xeomin(®)) in cervical dystonia.Journal of neural transmission (Vienna, Austria : 1996) · 2013Trial
- Long-term efficacy and safety of incobotulinumtoxinA injections in patients with cervical dystonia.Journal of neurology, neurosurgery, and psychiatry · 2013Trial
- Pilot study of topical acetyl hexapeptide-8 in the treatment for blepharospasm in patients receiving botulinum toxin therapy.European journal of neurology · 2013Trial
88 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 7 institutions in 3 countries.
Funding
Abstract
objectiveTo perform an evidence-based review of the safety and efficacy of botulinum neurotoxin (BoNT) in the treatment of movement disorders.
methodsA literature search was performed including MEDLINE and Current Contents for therapeutic articles relevant to BoNT and selected movement disorders. Authors reviewed, abstracted, and classified articles based on American Academy of Neurology criteria (Class I-IV).
resultsThe highest quality literature available for the respective indications was as follows: blepharospasm (two Class II studies); hemifacial spasm (one Class II and one Class III study); cervical dystonia (seven Class I studies); focal upper extremity dystonia (one Class I and three Class II studies); focal lower extremity dystonia (one Class II study); laryngeal dystonia (one Class I study); motor tics (one Class II study); and upper extremity essential tremor (two Class II studies). RECOMMENDATIONS: Botulinum neurotoxin should be offered as a treatment option for the treatment of cervical dystonia (Level A), may be offered for blepharospasm, focal upper extremity dystonia, adductor laryngeal dystonia, and upper extremity essential tremor (Level B), and may be considered for hemifacial spasm, focal lower limb dystonia, and motor tics (Level C). While clinicians' practice may suggest stronger recommendations in some of these indications, evidence-based conclusions are limited by the availability of data.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.