ArticleGenetics2008
Genome integrity is regulated by the Caenorhabditis elegans Rad51D homolog rfs-1.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Transgenerational Sterility of a TransgenicmicroPublication biology · 2024Article
- DNA repair, recombination, and damage signaling.Genetics · 2022Review
- ZSWIM7 Is Associated With Human Female Meiosis and Familial Primary Ovarian Insufficiency.The Journal of clinical endocrinology and metabolism · 2022Article
- Molecular basis of reproductive senescence: insights from model organisms.Journal of assisted reproduction and genetics · 2021Review
- Article
- Intergenerational and transgenerational epigenetic inheritance in animals.Nature cell biology · 2019Review
- Multiple Histone Methyl-Lysine Readers Ensure Robust Development and Germline Immortality inGenetics · 2018Article
- Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination.Nature communications · 2018Article
- Natural Genetic Variation in a Multigenerational Phenotype in C. elegans.Current biology : CB · 2018Article
- Article
- JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity.PLoS genetics · 2017Article
- X Chromosome Crossover Formation and Genome Stability in Caenorhabditis elegans Are Independently Regulated by xnd-1.G3 (Bethesda, Md.) · 2016Article
- Promotion of Homologous Recombination by SWS-1 in Complex with RAD-51 Paralogs in Caenorhabditis elegans.Genetics · 2016Article
- Synthetic cytotoxicity: digenic interactions with TEL1/ATM mutations reveal sensitivity to low doses of camptothecin.Genetics · 2014Article
- A role for the malignant brain tumour (MBT) domain protein LIN-61 in DNA double-strand break repair by homologous recombination.PLoS genetics · 2013Article
- Interactions among Trypanosoma brucei RAD51 paralogues in DNA repair and antigenic variation.Molecular microbiology · 2011Article
- Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Cancer models in Caenorhabditis elegans.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple mechanisms ensure genome maintenance through DNA damage repair, suppression of transposition, and telomere length regulation. The mortal germline (Mrt) mutants in Caenorhabditis elegans are defective in maintaining genome integrity, resulting in a progressive loss of fertility over many generations. Here I show that the high incidence of males (him)-15 locus, defined by the deficiency eDf25, is allelic to rfs-1, the sole rad-51 paralog group member in C. elegans. The rfs-1/eDf25 mutant displays a Mrt phenotype and mutant animals manifest features of chromosome fusions prior to the onset of sterility. Unlike other Mrt genes, rfs-1 manifests fluctuations in telomere lengths and functions independently of telomerase. These data suggest that rfs-1 is a novel regulator of genome stability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.