ArticleGenetics2008
High rates of "unselected" aneuploidy and chromosome rearrangements in tel1 mec1 haploid yeast strains.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- A tale of two serines: the effects of histone H2A mutations S122A and S129A on chromosome nondisjunction in Saccharomyces cerevisiae.Genetics · 2025Article
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- RecBCD coordinates repair of two ends at a DNA double-strand break, preventing aberrant chromosome amplification.Nucleic acids research · 2018Article
- Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling.Genes & development · 2018Article
- Emerging and evolving concepts in gene essentiality.Nature reviews. Genetics · 2018Review
- Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells.Oncogenesis · 2017Article
- iSeq: A New Double-Barcode Method for Detecting Dynamic Genetic Interactions in Yeast.G3 (Bethesda, Md.) · 2017Article
- The nonessentiality of essential genes in yeast provides therapeutic insights into a human disease.Genome research · 2016Article
- Mutational landscape of yeast mutator strains.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Nonrandom distribution of interhomolog recombination events induced by breakage of a dicentric chromosome in Saccharomyces cerevisiae.Genetics · 2013Article
- Article
- Recurrent rearrangement during adaptive evolution in an interspecific yeast hybrid suggests a model for rapid introgression.PLoS genetics · 2013Article
- Gene copy-number variation in haploid and diploid strains of the yeast Saccharomyces cerevisiae.Genetics · 2013Article
- Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery.Genes & development · 2013Article
- Genome rearrangements caused by depletion of essential DNA replication proteins in Saccharomyces cerevisiae.Genetics · 2012Article
- Rapid analysis of Saccharomyces cerevisiae genome rearrangements by multiplex ligation-dependent probe amplification.PLoS genetics · 2012Article
- Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer.Current opinion in cell biology · 2010Review
- Chromosome rearrangements and aneuploidy in yeast strains lacking both Tel1p and Mec1p reflect deficiencies in two different mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Alterations in DNA replication and histone levels promote histone gene amplification in Saccharomyces cerevisiae.Genetics · 2010Article
- Stabilization of dicentric translocations through secondary rearrangements mediated by multiple mechanisms in S. cerevisiae.PloS one · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The yeast TEL1 and MEC1 genes (homologous to the mammalian ATM and ATR genes, respectively) serve partially redundant roles in the detection of DNA damage and in the regulation of telomere length. Haploid yeast tel1 mec1 strains were subcultured nonselectively for approximately 200 cell divisions. The subcultured strains had very high rates of chromosome aberrations: duplications, deletions, and translocations. The breakpoints of the rearranged chromosomes were within retrotransposons (Ty or delta-repeats), and these chromosome aberrations nonrandomly involved chromosome III. In addition, we showed that strains with the hypomorphic mec1-21 allele often became disomic for chromosome VIII. This property of the mec1-21 strains is suppressed by a plasmid containing the DNA2 gene (located on chromosome VIII) that encodes an essential nuclease/helicase involved in DNA replication and DNA repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.