ReviewJournal of hepatology2008
Mouse models for the study of HCV infection and virus-host interactions.
Review in Journal of hepatology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- Animal Models Used in Hepatitis C Virus Research.International journal of molecular sciences · 2020Review
- Human Immune System Mice With Autologous Tumor for Modeling Cancer Immunotherapies.Frontiers in immunology · 2020Review
- The Strange, Expanding World of Animal Hepaciviruses.Annual review of virology · 2016Review
- Parallel expression profiling of hepatic and serum microRNA-122 associated with clinical features and treatment responses in chronic hepatitis C patients.Scientific reports · 2016Article
- Roles of lipoprotein receptors in the entry of hepatitis C virus.World journal of hepatology · 2015Review
- Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.Science translational medicine · 2015Article
- Tumor-related gene changes in immunosuppressive Syrian hamster cholangiocarcinoma.Pathology oncology research : POR · 2013Article
- Current progress in development of hepatitis C virus vaccines.Nature medicine · 2013Review
- Immunosuppressive prednisolone enhances early cholangiocarcinoma in Syrian hamsters with liver fluke infection and administration of N-nitrosodimethylamine.Pathology oncology research : POR · 2013Article
- Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus.PloS one · 2013Article
- Over-expression of uPA increases risk of liver injury in pAAV-HBV transfected mice.World journal of gastroenterology · 2012Article
- Development of persistent HCV genotype 3a infection cell culture model in huh-7 cell.Virology journal · 2012Article
- Hepatocellular carcinoma xenograft supports HCV replication: a mouse model for evaluating antivirals.World journal of gastroenterology · 2011Article
- Article
- Replication of subgenomic hepatitis C virus replicons in mouse fibroblasts is facilitated by deletion of interferon regulatory factor 3 and expression of liver-specific microRNA 122.Journal of virology · 2010Article
- Viral hepatocarcinogenesis.Oncogene · 2010Review
- Moving closer to a mouse model for hepatitis C.Nature medicine · 2009Article
- Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection.World journal of gastroenterology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Hepatitis C virus (HCV) is a major cause of chronic liver disease including steatosis, cirrhosis and hepatocellular carcinoma. The development of transgenic mice expressing HCV proteins and the successful repopulation of SCID/Alb-uPA mice with human hepatocytes provides an important tool for unraveling virus-host interactions in vivo. Several of these mouse models exhibit aspects of HCV-related liver disease. Thus, these in vivo models play an important role to further understand the pathogenesis of HCV infection and to evaluate the pre-clinical safety and efficacy of new antiviral compounds against HCV. This review summarizes the most important mouse models currently used to study HCV pathogenesis and infection. Finally, the perspective of these models for future HCV research as well as the design of novel small animal models is discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.