ArticleBMC developmental biology2008
Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans.
Article in BMC developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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Who cites it
87 citing papers in PubMed, 134 citations in OpenAlex.
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- Rewarding touch limits lifespan through neural to intestinal signaling.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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- Perception and Longevity Control in Invertebrate Model Organisms-A Mini-Review of Recent Advances.Biomolecules · 2025Review
- findWormz is a user-friendly automated fluorescence quantification method formicroPublication biology · 2025Article
- Fmo induction as a tool to screen for pro-longevity drugs.GeroScience · 2024Article
- Polyethylene glycol as an improved barrier to prevent fleeing inmicroPublication biology · 2024Article
- Sis2 regulates yeast replicative lifespan in a dose-dependent manner.Nature communications · 2023Article
- Effects of hunger on neuronal histone modifications slow aging inScience (New York, N.Y.) · 2023Article
- Endogenous DAF-16 spatiotemporal activity quantitatively predicts lifespan extension induced by dietary restriction.Communications biology · 2023Article
- C22 disrupts embryogenesis and extendsFrontiers in physiology · 2023Article
- Serotonin and dopamine modulate aging in response to food odor and availability.Nature communications · 2022Article
- Phosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans.Nature communications · 2022Article
- Fitness benefits of dietary restriction.Proceedings. Biological sciences · 2021Article
- Article
- Transgenerational fitness effects of lifespan extension by dietary restriction inProceedings. Biological sciences · 2021Article
- Yeast volatiles double starvation survival inScience advances · 2021Article
27 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDietary restriction (DR) increases life span and delays age-associated disease in many organisms. The mechanism by which DR enhances longevity is not well understood.
resultsUsing bacterial food deprivation as a means of DR in C. elegans, we show that transient DR confers long-term benefits including stress resistance and increased longevity. Consistent with studies in the fruit fly and in mice, we demonstrate that DR also enhances survival when initiated late in life. DR by bacterial food deprivation significantly increases life span in worms when initiated as late as 24 days of adulthood, an age at which greater than 50% of the cohort have died. These survival benefits are, at least partially, independent of food consumption, as control fed animals are no longer consuming bacterial food at this advanced age. Animals separated from the bacterial lawn by a barrier of solid agar have a life span intermediate between control fed and food restricted animals. Thus, we find that life span extension from bacterial deprivation can be partially suppressed by a diffusible component of the bacterial food source, suggesting a calorie-independent mechanism for life span extension by dietary restriction.
conclusionBased on these findings, we propose that dietary restriction by bacterial deprivation increases longevity in C. elegans by a combination of reduced food consumption and decreased food sensing.
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