Evidence map›Paper›PMID 18457244›Full record

ArticleSleep2008

Sleep-disordered breathing and cardiovascular disease in the Bay Area Sleep Cohort.

Yohannes W Endeshaw, Heather L Bloom, Donald L Bliwise

Open access · bronzeAbstract read
In one paragraph

Article in Sleep, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Article
  5. Neurocognitive correlates of nocturnal oxygen desaturation in a memory clinic population.Journal of clinical and experimental neuropsychology · 2012
    Article
  6. Article
  7. Incident sleep disordered breathing in old age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2010
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yohannes W EndeshawDivision of Geriatrics & Gerontology, Emory University School of Medicine, Atlanta, GA 30329, USA. yendesh@emory.edu
Heather L Bloom
Donald L Bliwise
Emory University · US

Funding

Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Mentored Clinical Research Scholar ProgramK12RR017643 · NCRR · EMORY UNIVERSITY · PI BLUMBERG, HENRY M · 2002 to 2006
$5.1M
Biomarkers of Aging in the Bay Area Sleep CohortR01AG020269 · NIA · EMORY UNIVERSITY · PI BLIWISE, DONALD L. · 2003 to 2005
$896k
Nocturnal Polyuria and Sleep-disordered breathingK23AG025963 · NIA · EMORY UNIVERSITY · PI ENDESHAW, YOHANNES W · 2005 to 2009
$636k
FOLLOW-UP OF ELDERLY PATIENTS WITH SLEEP APNEAR01AG006066 · NIA · STANFORD UNIVERSITY · PI DEMENT, WILLIAM C · 1987 to 1991
–
NCATS NIH HHS UL1 TR000454NCRR NIH HHS K12 RR 017643NCRR NIH HHS K12 RR017643NIA NIH HHS K23 AG 025963NIA NIH HHS K23 AG025963NIA NIH HHS R01 AG-020269NIA NIH HHS R01 AG020269NIA NIH HHS R01 AG-06066
6 · The paper itself

Abstract

STUDY

objectivesTo examine the relationship between sleep-disordered breathing (SDB) and cardiovascular disease among community-dwelling older adults. Previous studies have suggested relatively stronger associations between SDB and such morbidity in middle-aged, relative to elderly, populations.

designCross-sectional analysis of an elderly ambulatory, non-clinic-based cohort (Bay Area Sleep Cohort, BASC)

settingCommunity population studied in a sleep laboratory

participantsOne hundred twenty-nine older adults (mean [+/- SD] age = 72.6 [8.3]) (78 women; 51 men).

interventionsNA. MEASUREMENTS: Complete clinical history including list of current medications, physical examination, selected blood chemistries, multiple blood pressure measurements, 12-lead electrocardiogram, and 2 consecutive nights of polysomnography.

resultsFifty-one individuals (40%) were taking 1 or more cardiovascular medications and 24 (19%) had an apnea-hypopnea index (AHI) of 10 or more per hour of sleep. Cardiovascular medication use was related to cardiac events or procedures, history of angina, higher systolic or diastolic blood pressure, and abnormal electrocardiogram. Logistic regression showed statistically significant association between cardiovascular medication use and AHI of 10 or greater per hour, independent of age, sex, and body mass index. Supplementary analyses indicated that rapid eye movement AHI of 10 or greater per hour was significantly associated with elevated diastolic blood pressure.

conclusionsThe results suggest that sleep-disordered breathing may contribute to increased cardiovascular morbidity in older adults.

Indexed as

AgedCardiovascular DiseasesCatchment Area, HealthCohort StudiesCross-Sectional StudiesElectrocardiographyFemaleFollow-Up StudiesGeorgiaHumansMaleMiddle AgedPhysical ExaminationPolysomnographyPrevalenceProspective Studies

Identifiers

PMID18457244
PMCPMC2279747
OpenAlexW2189063419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.