Evidence map›Paper›PMID 18457003›Full record

ArticleActa neurochirurgica. Supplement2008

Role of statins in cerebral vasospasm.

T Sugawara, R Ayer, J H Zhang

Open access · greenAbstract read
In one paragraph

Article in Acta neurochirurgica. Supplement, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Statins in the critically ill.Annals of intensive care · 2012
    Article
  7. Pleiotropic effects of the HMG-CoA reductase inhibitors.International journal of general medicine · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

T SugawaraDepartment of Physiology and Pharmacology, Loma Linda University Medical School, Loma Linda, California 92354, USA.
R Ayer
J H Zhang
Loma Linda University · US

Funding

Mechanisms of Hyperbaric Oxygen Induced Brain ProtectionR01NS043338 · NINDS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ZHANG, JOHN H · 2004 to 2014
$3.0M
Neurovascular Protection for Subarachnoid HemorrhageR01NS053407 · NINDS · LOMA LINDA UNIVERSITY · PI ZHANG, JOHN H · 2006 to 2010
$1.8M
Oxygen Therapy in Neonatal Hypoxia-IschemiaR01HD043120 · NICHD · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ZHANG, JOHN H. · 2003 to 2007
$1.6M
Anti-apoptosis as a new therapy for cerebral vasospasmR01NS045694 · NINDS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ZHANG, JOHN H. · 2002 to 2005
$1.1M
NICHD NIH HHS HD43120NICHD NIH HHS R01 HD043120NINDS NIH HHS NS43338NINDS NIH HHS NS45694NINDS NIH HHS NS53407NINDS NIH HHS R01 NS043338NINDS NIH HHS R01 NS045694NINDS NIH HHS R01 NS053407
6 · The paper itself

Abstract

3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors, commonly known as statins, are widely used clinically for their lipid lowering properties. Recent evidence shows that statins are also effective in ameliorating cerebral vasospasm, which occurs as sequelae of subarachnoid haemorrhage. This review focuses on the pleiotropic effects of statins, and the putative mechanisms involved in statin mediated attenuation of cerebral vasospasm.

Indexed as

AnimalsDisease Models, AnimalHydroxymethylglutaryl-CoA Reductase InhibitorsMuscle, Smooth, VascularNitric Oxide Synthase Type IIISubarachnoid HemorrhageVasospasm, IntracranialHydroxymethylglutaryl-CoA Reductase InhibitorsNitric Oxide Synthase Type III

Identifiers

PMID18457003
PMCPMC2743544
OpenAlexW56705656

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.