ArticleBlood2008
Osteolineage niche cells initiate hematopoietic stem cell mobilization.
Article in Blood, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 101 citations in OpenAlex.
- Effects of resistance training on biomarkers of bone formation and association with red blood cell variables.Journal of physiology and biochemistry · 2011Trial
- Article
- Emerging insights into epigenetics and hematopoietic stem cell trafficking in age-related hematological malignancies.Stem cell research & therapy · 2024Review
- Age-related differences in the bone marrow stem cell niche generate specialized microenvironments for the distinct regulation of normal hematopoietic and leukemia stem cells.Scientific reports · 2019Article
- A novel 3D mesenchymal stem cell model of the multiple myeloma bone marrow niche: biologic and clinical applications.Oncotarget · 2016Article
- Hematopoietic stem cells: multiparameter regulation.Human cell · 2016Review
- Adhesion receptors involved in HSC and early-B cell interactions with bone marrow microenvironment.Cellular and molecular life sciences : CMLS · 2016Review
- Article
- Targeting stem cell niche can protect hematopoietic stem cells from chemotherapy and G-CSF treatment.Stem cell research & therapy · 2015Article
- Article
- Ability of circulating human hematopoietic lineage negative cells to support hematopoiesis.Journal of cellular biochemistry · 2015Article
- Article
- Bone marrow vascular niche: home for hematopoietic stem cells.Bone marrow research · 2014Review
- The lost intrinsic fragmentation of MAT1 protein during granulopoiesis promotes the growth and metastasis of leukemic myeloblasts.Stem cells (Dayton, Ohio) · 2013Article
- Pyk2 regulates megakaryocyte-induced increases in osteoblast number and bone formation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013Article
- Article
- Mesenchymal stem cells in immune-mediated bone marrow failure syndromes.Clinical & developmental immunology · 2013Review
- Differential regulation of CXCL5 by FGF2 in osteoblastic and endothelial niche cells supports hematopoietic stem cell migration.Stem cells and development · 2012Article
- Molecular signature and in vivo behavior of bone marrow endosteal and subendosteal stromal cell populations and their relevance to hematopoiesis.Experimental cell research · 2012Article
- Tug of war in the haematopoietic stem cell niche: do myeloma plasma cells compete for the HSC niche?Blood cancer journal · 2012Article
Corrections and comments
- Expression of concern · 2008-10-14Concerns/Issues about Data · Concerns/Issues about Image · · Shane Mayack has NIH finding of misconduct: https://grants.nih.gov/grants/guide/notice-files/NOT-OD-12-147.html
- Retraction · 2012-02-16Duplication of Data · Investigation by Company/Institution · Investigation by Journal/Publisher · Investigation by ORI · Manipulation of Images · Objections by Author(s) · · Shane Mayack has NIH finding of misconduct: https://grants.nih.gov/grants/guide/notice-files/NOT-OD-12-147.html
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- Retracted
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Recent studies have implicated bone-lining osteoblasts as important regulators of hematopoietic stem cell (HSC) self-renewal and differentiation; however, because much of the evidence supporting this notion derives from indirect in vivo experiments, which are unavoidably complicated by the presence of other cell types within the complex bone marrow milieu, the sufficiency of osteoblasts in modulating HSC activity has remained controversial. To address this, we prospectively isolated mouse osteoblasts, using a novel flow cytometry-based approach, and directly tested their activity as HSC niche cells and their role in cyclophosphamide/granulocyte colony-stimulating factor (G-CSF)-induced HSC proliferation and mobilization. We found that osteoblasts expand rapidly after cyclophosphamide/G-CSF treatment and exhibit phenotypic and functional changes that directly influence HSC proliferation and maintenance of reconstituting potential. Effects of mobilization on osteoblast number and function depend on the function of ataxia telangiectasia mutated (ATM), the product of the Atm gene, demonstrating a new role for ATM in stem cell niche activity. These studies demonstrate that signals from osteoblasts can directly initiate and modulate HSC proliferation in the context of mobilization. This work also establishes that direct interaction with osteolineage niche cells, in the absence of additional environmental inputs, is sufficient to modulate stem cell activity.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.