Evidence map›Paper›PMID 18456530›Full record

ArticleJournal of clinical densitometry : the official journal of the International Society for Clinical Densitometry

Muscle mass is more strongly related to hip bone mineral density than is quadriceps strength or lower activity level in adults over age 50 year.

Neil A Segal, James C Torner, Mei Yang, Jeffrey R Curtis, David T Felson, Michael C Nevitt, Multicenter Osteoarthritis Study Group

Abstract read
In one paragraph

Article in Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
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  10. The negative effect of unloading exceeds the bone-sparing effect of alkaline supplementation: a bed rest study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Article
  11. Article
  12. Article
  13. Review
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  15. Association between change in body weight after midlife and risk of hip fracture-the Singapore Chinese Health Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Article
  16. Article
  17. Muscle size, strength, and physical performance and their associations with bone structure in the Hertfordshire Cohort Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013
    Article
  18. Article
  19. The Multicenter Osteoarthritis Study: opportunities for rehabilitation research.PM & R : the journal of injury, function, and rehabilitation · 2013
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Neil A SegalDepartment of Orthopaedics & Rehabilitation, University of Iowa and VA Medical Center, Iowa City, IA 52242-1088, USA. neil-segal@uiowa.edu
James C Torner
Mei Yang
Jeffrey R Curtis
David T Felson
Michael C Nevitt
Multicenter Osteoarthritis Study Group

Funding

Multicenter Osteoarthritis Study (MOST) Second RenewalU01AG019069 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NEVITT, MICHAEL C · 2001 to 2020
$21.7M
Rehabilitation Medicine Scientist Training (RMST) ProgramK12HD001097 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BONINGER, MICHAEL L. · 1995 to 2016
$14.1M
Multicenter Osteoarthritis Study (MOST) Second Renewal: Iowa Clinical CenterU01AG018832 · NIA · UNIVERSITY OF IOWA · PI SEGAL, NEIL A, TORNER, JAMES C · 2001 to 2020
$14.1M
Multicenter Osteoarthritis Study (MOST) Second Renewal - Boston UniversityU01AG018820 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FELSON, DAVID TOBIN · 2001 to 2019
$13.6M
Multicenter Osteoarthritis Study (MOST) Second Renewal - UAB Clinical CenterU01AG018947 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEWIS, CORA E · 2001 to 2020
$13.2M
NIA NIH HHS 1 U01 AG18820NIA NIH HHS 1 U01 AG18832NIA NIH HHS 1 U01 AG18947NIA NIH HHS 1 U01 AG19069NIA NIH HHS U01 AG018820NIA NIH HHS U01 AG018832NIA NIH HHS U01 AG018947NIA NIH HHS U01 AG019069NICHD NIH HHS 5K12HD001097-08NICHD NIH HHS K12 HD001097
6 · The paper itself

Abstract

This cross-sectional study examined whether reduced hip bone mineral density (BMD) is better explained by isokinetic knee extensor strength (KES), lower limb lean body mass (L-LBM), or Physical Activity Scale for the Elderly (PASE). Through population-based recruitment, 1543 adults without knee osteoarthritis were recruited. For men and women respectively, means+/-SD were age 60.8+/-8.0 and 61.1+/-7.9 yr; body mass index 29.6+/-4.6 and 29.1+/-5.4 kg/m(2); hip BMD 1.025+/-0.138 and 0.895+/-0.128 g/cm(2); KES 124.9+/-41 and 72.7+/-22.9 N.m; L-LBM 10.3+/-1.5 and 7.0+/-1.2 kg; and PASE 206.4+/-99.7 and 163.8+/-77.0. The relationship between BMD and KES in men (r(2)=0.21, p> or =0.002) and women (r=0.23, p<0.001) was significant before adjustment. However, this association was no longer significant after controlling for L-LBM. Even after controlling for age, race, and sex, the association between BMD and KES was better explained by L-LBM (partial R(2)=0.14, p<0.001) than by PASE (partial R(2)=0.00). Allometric scaling of KES to body size attenuated the association of BMD with KES (Std Beta=0.03). The significant association between BMD and L-LBM (Std Beta=0.36) remained stronger than that between BMD and weight (Std Beta=0.21). Therefore, muscle mass accounted for a greater proportion of the variance in hip BMD than KES or activity level and explained a significant proportion of the association between weight and BMD.

Indexed as

Absorptiometry, PhotonAgedAnalysis of VarianceBody CompositionBody Mass IndexBone DensityCross-Sectional StudiesFemaleHip JointHumansKnee JointMaleMiddle AgedMotor ActivityMuscle, SkeletalMuscle Strength

Identifiers

PMID18456530
PMCPMC2654209

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.