ReviewCurrent opinion in immunology2008
The thymus chapter in the life of gut-specific intra epithelial lymphocytes.
Review in Current opinion in immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Single-cell transcriptomic profiling reveals innate-like cytotoxic intraepithelial lymphocyte expansion duringFrontiers in immunology · 2026Article
- The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβCell death and differentiation · 2022Article
- Exposures to uranium and arsenic alter intraepithelial and innate immune cells in the small intestine of male and female mice.Toxicology and applied pharmacology · 2020Article
- Retinoid Signaling in Intestinal Epithelial Cells Is Essential for Early Survival From Gastrointestinal Infection.Frontiers in immunology · 2020Article
- Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling.Nature immunology · 2019Article
- Sentinels at the frontline: the role of intraepithelial lymphocytes in inflammatory bowel disease.Current pharmacology reports · 2017Article
- γδ T cells in homeostasis and host defence of epithelial barrier tissues.Nature reviews. Immunology · 2017Review
- Pathogenesis of NEC: Role of the innate and adaptive immune response.Seminars in perinatology · 2017Review
- CD8αα TCRαβ Intraepithelial Lymphocytes in the Mouse Gut.Digestive diseases and sciences · 2016Review
- Themis sets the signal threshold for positive and negative selection in T-cell development.Nature · 2013Article
- Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes.The Journal of experimental medicine · 2013Article
- Selection of self-reactive T cells in the thymus.Annual review of immunology · 2012Review
- The light and dark sides of intestinal intraepithelial lymphocytes.Nature reviews. Immunology · 2011Review
- Tissue-based class control: the other side of tolerance.Nature reviews. Immunology · 2011Review
- Intrinsic requirement for the vitamin D receptor in the development of CD8αα-expressing T cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Why do T cells express the vitamin D receptor?Annals of the New York Academy of Sciences · 2011Review
- Krüppel-like factor 2 regulates trafficking and homeostasis of gammadelta T cells.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Trans-presentation of IL-15 by intestinal epithelial cells drives development of CD8alphaalpha IELs.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Intestinal T cells: facing the mucosal immune dilemma with synergy and diversity.Seminars in immunology · 2009Review
- The L2a element is a mouse CD8 silencer that interacts with MAR-binding proteins SATB1 and CDP.Molecular immunologyArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The intestinal intraepithelial lymphocytes (IEL) represent multi-lineage T cell populations. In addition to a major gammadeltaTCR(+) T cell subset, many IEL express alphabetaTCRs and they can be separated into alphabeta sublineages. Some TCRalphabeta(+)IEL have characteristics in common with conventional TCRalphabeta(+)T cells whereas others share an unconventional phenotype with their TCRgammadelta(+) counterparts. Because the latter are enriched for autoreactive TCRs and can be generated in the absence of a thymus, it has long been postulated that some IEL subsets develop locally in the intestine. Several new data however, indicate that under physiological conditions, IEL require a thymic education that directs lineage commitment and functional differentiation. This review will discuss the contributions of the thymus in shaping the various intestinal IEL sublineages.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.