ReviewCurrent opinion in immunology2008
T cell receptor specificity for major histocompatibility complex proteins.
Review in Current opinion in immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- PPARδ restrains the suppression function of intra-tumoral Tregs by limiting CIITA-MHC II expression.bioRxiv : the preprint server for biology · 2024Article
- Benchmarking data-driven filtering for denoising of TCRpMHC single-cell data.Scientific reports · 2023Article
- Controllable assembly of synthetic constructs with programmable ternary DNA interaction.Nucleic acids research · 2022Article
- A framework for highly multiplexed dextramer mapping and prediction of T cell receptor sequences to antigen specificity.Science advances · 2021Article
- CD4 T cells in protection from influenza virus: Viral antigen specificity and functional potential.Immunological reviews · 2018Review
- Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity.Cell · 2014Article
- Parallel affinity-based isolation of leukocyte subsets using microfluidics: application for stroke diagnosis.Analytical chemistry · 2014Article
- Subtle changes in TCRα CDR1 profoundly increase the sensitivity of CD4 T cells.Molecular immunology · 2013Article
- Binding of TCR multimers and a TCR-like antibody with distinct fine-specificities is dependent on the surface density of HLA complexes.PloS one · 2012Article
- Article
- Elevated tumor-associated antigen expression suppresses variant peptide vaccine responses.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Generation of MHC class II-peptide ligands for CD4 T-cell allorecognition of MHC class II molecules.Current opinion in organ transplantation · 2010Review
- Periplasmic expression of soluble single chain T cell receptors is rescued by the chaperone FkpA.BMC biotechnology · 2010Article
- Many different Vbeta CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- [From stem cells to lymphocytes].Zeitschrift fur Rheumatologie · 2009Review
- Conformational changes within the HLA-A1:MAGE-A1 complex induced by binding of a recombinant antibody fragment with TCR-like specificity.Protein science : a publication of the Protein Society · 2009Article
- Immune evasion by TGFβ-induced miR-183 repression of MICA/B expression in human lung tumor cells.OncoimmunologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The ligands for alpha beta T cell receptors (alphabetaTCRs) are usually major histocompatibility complex (MHC) proteins bound to peptides. Although there is evidence that T cell receptor variable regions have been selected evolutionarily to bind MHC, the rules governing this interaction have not previously been apparent. However, recent solved structures of T cell receptors with related variable regions bound to MHC plus peptides suggest that some amino acids in variable region CDR1 and CDR2s almost always react in a consistent way with MHC. These amino acids may therefore have been selected evolutionarily to predispose T cell receptors toward recognition of MHC ligands.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.