Evidence map›Paper›PMID 18456037›Full record

SynthesisThe American journal of medicine2008

Association between alcohol consumption and both osteoporotic fracture and bone density.

Karina M Berg, Hillary V Kunins, Jeffrey L Jackson, Shadi Nahvi, Amina Chaudhry, Kenneth A Harris, Rubina Malik, Julia H Arnsten

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

134 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  4. Alcohol consumption and hip fracture risk.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
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74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Karina M BergDepartment of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10467, USA. kberg@montefiore.org
Hillary V Kunins
Jeffrey L Jackson
Shadi Nahvi
Amina Chaudhry
Kenneth A Harris
Rubina Malik
Julia H Arnsten

Funding

Immunology/Pathology CoreP30AI051519 · NIAID · YESHIVA UNIVERSITY · PI GOLDSTEIN, HARRIS · 2003 to 2013
$18.6M
Efficacy and cost of HAART DOT in methadone clinicsR01DA015302 · NIDA · YESHIVA UNIVERSITY · PI ARNSTEN, JULIA H · 2003 to 2007
$4.8M
HIV and Substance Abuse Clinical Addiction Research and Education (CARE) ProgramR25DA023021 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ARNSTEN, JULIA H. · 2007 to 2014
$2.7M
CLINICAL ADDICTION RESEARCH AND EDUCATION (CARE) PROGRAMR25DA014551 · NIDA · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ARNSTEN, JULIA H. · 2002 to 2005
$1.3M
Improving Measurement of Antiretroviral Adherence in Current and Former Drug UserK23DA021087 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI BERG, KARINA M · 2006 to 2009
$647k
NIAID NIH HHS P30 AI051519NIAID NIH HHS P30 AI51519NIDA NIH HHS K23 DA021087NIDA NIH HHS R01 DA015302NIDA NIH HHS R25 DA014551NIDA NIH HHS R25 DA023021NIDA NIH HHS R25 DA14551
6 · The paper itself

Abstract

objectiveAlcoholism is a risk factor for osteoporotic fractures and low bone density, but the effects of moderate alcohol consumption on bone are unknown. We performed a systematic review and meta-analysis to assess the associations between alcohol consumption and osteoporotic fractures, bone density and bone density loss over time, bone response to estrogen replacement, and bone remodeling.

methodsMEDLINE, Current Contents, PsychINFO, and Cochrane Libraries were searched for studies published before May 14, 2007. We assessed quality using the internal validity criteria of the US Preventive Services Task Force.

resultsWe pooled effect sizes for 2 specific outcomes (hip fracture and bone density) and synthesized data qualitatively for 4 outcomes (non-hip fracture, bone density loss over time, bone response to estrogen replacement, and bone remodeling). Compared with abstainers, persons consuming from more than 0.5 to 1.0 drinks per day had lower hip fracture risk (relative risk=0.80 [95% confidence interval, 0.71-0.91]), and persons consuming more than 2 drinks per day had higher risk (relative risk=1.39 [95% confidence interval, 1.08-1.79]). A linear relationship existed between femoral neck bone density and alcohol consumption. Because studies often combined moderate and heavier drinkers in a single category, we could not assess relative associations between alcohol consumption and bone density in moderate compared with heavy drinkers.

conclusionCompared with abstainers and heavier drinkers, persons who consume 0.5 to 1.0 drink per day have a lower risk of hip fracture. Although available evidence suggests a favorable effect of alcohol consumption on bone density, a precise range of beneficial alcohol consumption cannot be determined.

Indexed as

Alcohol DrinkingBone DensityDose-Response Relationship, DrugEthanolHip FracturesHumansOsteoporosisEthanol

Identifiers

PMID18456037
PMCPMC2692368

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.