ArticleBrain research2008
Rapid eye movement (REM) sleep homeostatic regulatory processes in the rat: changes in the sleep-wake stages and electroencephalographic power spectra.
Article in Brain research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
- Sleep fragmentation intensifies sleep architecture disruption and fatigue after traumatic brain injury.Experimental neurology · 2026Article
- Homeostatic regulation of rapid eye movement sleep by the preoptic area of the hypothalamus.eLife · 2024Article
- Homeostatic regulation of REM sleep by the preoptic area of the hypothalamus.bioRxiv : the preprint server for biology · 2024Article
- Early- and late-onset narcolepsy: possibly two distinct clinical phenotypes.Sleep & breathing = Schlaf & Atmung · 2023Article
- Probing pathways by which rhynchophylline modifies sleep using spatial transcriptomics.Biology direct · 2023Article
- GABAergic neurons in the rostromedial tegmental nucleus are essential for rapid eye movement sleep suppression.Nature communications · 2022Article
- The Elusive "Switch Process" in Bipolar Disorder and Photoperiodism: A Hypothesis Centering on NADPH Oxidase-Generated Reactive Oxygen Species Within the Bed Nucleus of the Stria Terminalis.Frontiers in psychiatry · 2022Article
- A probabilistic model for the ultradian timing of REM sleep in mice.PLoS computational biology · 2021Article
- Neural and Homeostatic Regulation of REM Sleep.Frontiers in psychology · 2020Review
- Multilevel Interactions of Stress and Circadian System: Implications for Traumatic Stress.Frontiers in psychiatry · 2019Review
- Article
- Activation of brain-derived neurotrophic factor-tropomyosin receptor kinase B signaling in the pedunculopontine tegmental nucleus: a novel mechanism for the homeostatic regulation of rapid eye movement sleep.Journal of neurochemistry · 2017Article
- Differential modulation of global and local neural oscillations in REM sleep by homeostatic sleep regulation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Cellular and Molecular Mechanisms of REM Sleep Homeostatic Drive: A Plausible Component for Behavioral Plasticity.Frontiers in neural circuits · 2017Article
- The homeostatic regulation of REM sleep: A role for localized expression of brain-derived neurotrophic factor in the brainstem.Behavioural brain research · 2015Article
- Article
- Coupled flip-flop model for REM sleep regulation in the rat.PloS one · 2014Article
- REM sleep phase preference in the crepuscular Octodon degus assessed by selective REM sleep deprivation.Sleep · 2013Article
- Estradiol modulates recovery of REM sleep in a time-of-day-dependent manner.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Modulation of fronto-cortical activity by modafinil: a functional imaging and fos study in the rat.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The aim of this study was to elucidate physiological processes that are involved in the homeostatic regulation of REM sleep. Adult rats were chronically instrumented with sleep-wake recording electrodes. Following post-surgical recovery, rats were habituated extensively for freely moving polygraphic recording conditions. On the first experimental recording day (baseline day, BLD), polygraphic signs of undisturbed sleep-wake activities were recorded for 4 h (between 11:00 AM and 3:00 PM). During the second experimental recording day (REM sleep deprivation day, RDD), rats were selectively deprived of REM sleep for the first 2 h and then allowed to have normal sleep-wake for the following 2 h. The results demonstrated that during the first 2 h, compared to BLD, RDD recordings exhibited 87.80% less time in REM sleep and 16% more time in non-REM (NREM) sleep. The total percentages of wakefulness remained comparable between the BLD and RDD. During the RDD, the mean number of REM sleep episodes was much higher than in the BLD, indicating increased REM sleep drive. Electroencephalographic (EEG) power spectral analysis revealed that selective REM sleep deprivation increased delta power but decreased theta power during the residual REM sleep. During the last 2 h, after REM sleep deprivation, rats spent 51% more time in REM sleep compared to the BLD. Also during this period, the number of REM sleep episodes with the shortest (5-30 s) and longest (>120 s) duration increased during the RDD. These findings suggest that the REM sleep homeostatic process involves increased delta- and decreased theta-frequency wave activities in the cortical EEG.
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