Evidence map›Paper›PMID 18455526›Full record

Trial reportAmerican journal of obstetrics and gynecology2008

The impact of the active management of risk in pregnancy at term on birth outcomes: a randomized clinical trial.

James M Nicholson, Samuel Parry, Aaron B Caughey, Sarah Rosen, Allison Keen, George A Macones

Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in American journal of obstetrics and gynecology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Induction of labour at or beyond 37 weeks' gestation.The Cochrane database of systematic reviews · 2020
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Use of labour induction and risk of cesarean delivery: a systematic review and meta-analysis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2014
    Pooled it
  5. Pooled it
  6. Trial
  7. Article
  8. Association between weighted adverse outcome score and race/ethnicity in women and neonates.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Timing of delivery and pregnancy outcomes among laboring nulliparous women.American journal of obstetrics and gynecology · 2012
    Article
  14. Contemporary cesarean delivery practice in the United States.American journal of obstetrics and gynecology · 2010
    Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

James M NicholsonDepartment of Family Medicine and Community Health, University of Pennsylvania, Philadelphia, PA, USA.
Samuel Parry
Aaron B Caughey
Sarah Rosen
Allison Keen
George A Macones

Funding

Mentored Patient Oriented Career Development AwardK23HD042043 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI NICHOLSON, JAMES M · 2002 to 2006
$640k
NICHD NIH HHS K23 HD042043NICHD NIH HHS K23-HD-42043
6 · The paper itself

Abstract

objectiveThe purpose of this study was to compare birth outcomes that result from the active management of risk in pregnancy at term (AMOR-IPAT) to those outcomes that result from standard management. STUDY

designThis was a randomized clinical trial with 270 women of mixed parity. AMOR-IPAT used preventive labor induction to ensure delivery before the end of an estimated optimal time of delivery. Rates of 4 adverse obstetric events and 2 composite measures were used to evaluate birth outcomes.

resultsThe AMOR-IPAT-exposed group had a similar cesarean delivery rate (10.3% vs 14.9%; P = .25), but a lower neonatal intensive care unit admission rate (1.5% vs 6.7%; P = .03), a higher uncomplicated vaginal birth rate (73.5% vs 62.8%; P = .046), and a lower mean Adverse Outcome Index score (1.4 vs 8.6; P = .03).

conclusionAMOR-IPAT exposure improved the pattern of birth outcomes. Larger randomized clinical trials are needed to explore further the impact of AMOR-IPAT on birth outcomes and to determine the best methods of preventive labor induction.

Indexed as

Pregnancy, High-RiskPregnancy OutcomeAdultCesarean SectionFemaleGestational AgeHumansIntensive Care Units, NeonatalLabor, InducedOdds RatioPractice Patterns, Physicians'PregnancyProportional Hazards ModelsUrban Population

Identifiers

PMID18455526
PMCPMC2855849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.