ArticleMolecular immunology2008
Macrophages express multiple ligands for gammadelta TCRs.
Article in Molecular immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 25 citations in OpenAlex.
- Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis.Nature immunology · 2025Article
- Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis.bioRxiv : the preprint server for biology · 2024Article
- γδ T cell antigen receptor polyspecificity enables T cell responses to a broad range of immune challenges.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A blend of broadly-reactive and pathogen-selected Vγ4 Vδ1 T cell receptors confer broad bacterial reactivity of resident memory γδ T cells.Mucosal immunology · 2022Article
- Detection of Cell Surface Ligands for Human Synovial γδ T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Connection between γδ T-cell- and Adenosine- Mediated Immune Regulation in the Pathogenesis of Experimental Autoimmune Uveitis.Critical reviews in immunology · 2018Review
- A Highly Focused Antigen Receptor Repertoire Characterizes γδ T Cells That are Poised to Make IL-17 Rapidly in Naive Animals.Frontiers in immunology · 2015Article
- IL-23 receptor expression on γδ T cells correlates with their enhancing or suppressive effects on autoreactive T cells in experimental autoimmune uveitis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Retinoic acid inhibits CD25+ dendritic cell expansion and γδ T-cell activation in experimental autoimmune uveitis.Investigative ophthalmology & visual science · 2013Article
- Article
- Diversity of γδ T-cell antigens.Cellular & molecular immunology · 2013Review
- Activated gammadelta T cells promote the activation of uveitogenic T cells and exacerbate EAU development.Investigative ophthalmology & visual science · 2011Article
- Regulation and function of IL-17A- and IL-22-producing γδ T cells.Cellular and molecular life sciences : CMLS · 2011Review
- Targeting γδ T cells for immunotherapy of HIV disease.Future virology · 2011Article
- Resolution of allergic airway inflammation and airway hyperreactivity is mediated by IL-17-producing {gamma}{delta}T cells.American journal of respiratory and critical care medicine · 2010Article
- gammadeltaTCR ligands and lineage commitment.Seminars in immunology · 2010Review
- Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity.Nature reviews. Immunology · 2010Review
- Analysis of gamma delta T cell functions in the mouse.Journal of immunology (Baltimore, Md. : 1950) · 2010Review
- gammadelta T cells: the overlooked T-cell subset in demyelinating disease.Journal of neuroscience research · 2010Review
- Gammadelta T cells in EAE: early trafficking events and cytokine requirements.European journal of immunology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
As only a handful of ligands have been identified, the general nature of the ligands recognized by gammadelta T cells remains unresolved. In this study, soluble multimerized gammadelta T cell receptors (smTCRs) representing the TCRs of two gammadelta T cell subsets common in the mouse were used to detect and track their own ligands. Ligands for both subsets were found on resident peritoneal macrophages taken from untreated mice, and the expression of both was further induced by Listeria monocytogenes infection. Nevertheless, the two types of ligand differ from one another in abundance, in the kinetics of their induction following Listeria infection, and in their ability to be induced by in vitro culture with lipopolysaccharide (LPS). Surprisingly, because both are detectable on normal macrophages, these host-derived ligands are likely expressed constitutively, but are induced to higher levels of expression by stress or inflammation. In contrast to T22 and other known cell surface ligands for gammadelta T cells in mice and humans, expression of these smTCR-defined ligands does not depend on beta2-microglobulin, suggesting that they are not MHC class I or class I-like molecules.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.