ArticleMolecular and cellular biochemistry2008
Resveratrol inhibits cell growth by inducing cell cycle arrest in activated hepatic stellate cells.
Article in Molecular and cellular biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- The Application of Resveratrol Derivatives in Oral Cells Reduces the Oxidative Stress Induced by Glucocorticoids.Metabolites · 2024Article
- Therapeutic Applications of Resveratrol in Hepatic Encephalopathy through Its Regulation of the Microbiota, Brain Edema, and Inflammation.Journal of clinical medicine · 2021Review
- Towards resolving the enigma of the dichotomy of resveratrol: cis- and trans-resveratrol have opposite effects on TyrRS-regulated PARP1 activation.GeroScience · 2021Article
- Resveratrol increases the activation markers and changes the release of inflammatory cytokines of hepatic stellate cells.Molecular and cellular biochemistry · 2021Article
- Resveratrol Inhibits Particulate Matter-Induced Inflammatory Responses in Human Keratinocytes.International journal of molecular sciences · 2020Article
- Potential Adverse Effects of Resveratrol: A Literature Review.International journal of molecular sciences · 2020Review
- Therapeutic effect ofEXCLI journal · 2019Article
- 3,5-Diethoxy-3'-Hydroxyresveratrol (DEHR) Ameliorates Liver Fibrosis via Caveolin-1 Activation in Hepatic Stellate Cells and in a Mouse Model of Bile Duct Ligation Injury.Molecules (Basel, Switzerland) · 2018Article
- Resveratrol and liver: A systematic review.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Review
- Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease.World journal of hepatology · 2014Review
- Resveratrol induces mitochondria-mediated AIF and to a lesser extent caspase-9-dependent apoptosis in human lung adenocarcinoma ASTC-a-1 cells.Molecular and cellular biochemistry · 2011Article
- Effects of resveratrol on proliferation and apoptosis in rat ovarian theca-interstitial cells.Molecular human reproduction · 2010Article
- An antioxidant resveratrol significantly enhanced replication of hepatitis C virus.World journal of gastroenterology · 2010Article
- Resveratrol amplifies profibrogenic effects of free fatty acids on human hepatic stellate cells.Hepatology research : the official journal of the Japan Society of Hepatology · 2009Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resveratrol (RSV) exerts anti-proliferative and pro-apoptotic actions in different cell lines. Hepatic stellate cells (HSCs) are major fibrogenic cell types that contribute to collagen accumulation during chronic liver disease. In the present study, the inhibitory effects of RSV on cell proliferation, cell cycle, and apoptosis were evaluated in the mouse hepatic stellate cell line GRX. Cells treated with 1 nM-1 muM of RSV demonstrated a decrease in cell growth of about 35% after 5 days. GRX cells, treated with RSV (100 nM or 1 muM), were analyzed by flow cytometry; RSV induced an increase in the number of GRX cells in the S- and sub-G1 phases. The increase in sub-G1 phase cells and the nuclear condensation and fragmentation shown by DAPI staining identified a possible pro-apoptotic effect of RSV on GRX cells. Furthermore, the RSV anti-proliferative effects could be explained by an S-phase accumulation caused by a decrease in the progression through the cell cycle or an inhibition of S or G2 phase transition. It is notable that these RSV actions are mediated at nanomolar levels, compatible with the concentrations of free RSV in biological fluids after ingestion of polyphenol-rich foods, suggesting a possible effect of these foods as an adjuvant treatment in chronic liver diseases.
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