ArticleEuropean journal of nutrition2008
Low n-6:n-3 fatty acid ratio, with fish- or flaxseed oil, in a high fat diet improves plasma lipids and beneficially alters tissue fatty acid composition in mice.
Article in European journal of nutrition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 109 citations in OpenAlex.
- Effects of the n-6/n-3 polyunsaturated fatty acids ratio on postprandial metabolism in hypertriacylglycerolemia patients.Lipids in health and disease · 2013Trial
- Evaluation of the Optimum Dietary Arachidonic Acid Level and Its Essentiality for Black Seabream (Aquaculture nutrition · 2024Article
- A comprehensive review of the health benefits of flaxseed oil in relation to its chemical composition and comparison with other omega-3-rich oils.European journal of medical research · 2023Review
- Herbal Treatment of COPD and Asthma According to Persian Medicine: a Review of Current Evidence.Tanaffos · 2023Review
- Identification and quantification of lipids in wild and farmed Atlantic salmon (Food science & nutrition · 2022Article
- Physiological effects of an oil rich in γ-linolenic acid on hepatic fatty acid oxidation and serum lipid levels in genetically hyperlipidemic mice.Journal of clinical biochemistry and nutrition · 2019Article
- Effect of flaxseed oil supplementation on anthropometric and metabolic indices in patients with coronary artery disease: A double-blinded randomized controlled trial.Journal of cardiovascular and thoracic research · 2019Article
- Can the indicators of chronic ethanol consumption be minimized by a continuous flaxseed intake?International journal of experimental pathology · 2018Article
- Bioprocessing of Functional Ingredients from Flaxseed.Molecules (Basel, Switzerland) · 2018Review
- Green leafy vegetables in diets with a 25:1 omega-6/omega-3 fatty acid ratio modify the erythrocyte fatty acid profile of spontaneously hypertensive rats.Lipids in health and disease · 2018Article
- Identification and Quantification of Fatty Acids inJournal of lipids · 2018Article
- Article
- A Transgenic Camelina sativa Seed Oil Effectively Replaces Fish Oil as a Dietary Source of Eicosapentaenoic Acid in Mice.The Journal of nutrition · 2016Article
- Article
- Lowering the dietary omega-6: omega-3 does not hinder nonalcoholic fatty-liver disease development in a murine model.Nutrition research (New York, N.Y.) · 2015Article
- Flaxseed-a potential functional food source.Journal of food science and technology · 2015Review
- A Difference in Fatty Acid Composition of Isocaloric High-Fat Diets Alters Metabolic Flexibility in Male C57BL/6JOlaHsd Mice.PloS one · 2015Article
- Optimized rapeseed oils rich in endogenous micronutrients ameliorate risk factors of atherosclerosis in high fat diet fed rats.Lipids in health and disease · 2014Article
- Long-term obesity promotes alterations in diastolic function induced by reduction of phospholamban phosphorylation at serine-16 without affecting calcium handling.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- 17β-estradiol increases liver and serum docosahexaenoic acid in mice fed varying levels of α-linolenic acid.Lipids · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHealth benefits from low n-6:n-3 fatty acid (FA) ratio on cardiovascular risk have been shown. However, the impact of the source of n-3 FAs has not been fully investigated.
aimOur purpose was to investigate cardiovascular benefits of oils with a low ratio of n-6:n-3 FAs, but different sources of n-3 FAs in C57BL/6 mice.
methodsTwenty-one mice were divided into 3 groups (n=7) and fed a diet supplemented with either a fish or flaxseed oil-based 'designer oils' with an approximate n-6:n-3 FA ratio of 2/1 or with a safflower-oil-based diet with a ratio of 25/1, for 16 weeks. Plasma lipids and fatty acid profile of the liver tissue were characterized.
resultsCompared to baseline, plasma triacylglycerol levels declined (>50%) in all groups by week 4. Plasma cholesterol levels were reduced in both fish and flax groups by 27% and 36%, respectively, as compared to controls at endpoint. The levels of EPA and DHA in liver phospholipids were significantly increased in both fish and flax groups as compared to the control group, with more profound increases in the fish group. Arachidonic acid levels were similarly decreased in the liver tissues from both fish and flax groups as compared to controls.
conclusionsOur data suggest that health benefits may be achieved by lowering dietary n-6:n-3 FA even in a high fat diet medium.
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