ArticleMolecular and cellular biochemistry2008
Sphingosine 1-phosphate differentially regulates proliferation of C2C12 reserve cells and myoblasts.
Article in Molecular and cellular biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Myostatin Inhibitory D‑Peptides Induce Skeletal Muscle Hypertrophy along with Alteration of Bioactive Sphingolipid Metabolism.ACS pharmacology & translational science · 2026Article
- Grb2/Sos1 signaling regulates the number of reserve cells in C2C12 cell culture.In vitro cellular & developmental biology. Animal · 2026Article
- The TRPV1 Receptor Is Up-Regulated by Sphingosine 1-Phosphate and Is Implicated in the Anandamide-Dependent Regulation of Mitochondrial Activity in C2C12 Myoblasts.International journal of molecular sciences · 2022Article
- Sphingolipid Metabolism and Signaling in Skeletal Muscle: From Physiology to Physiopathology.Frontiers in endocrinology · 2020Review
- Sphingosine-1-phosphate pretreatment amends hypoxia-induced metabolic dysfunction and impairment of myogenic potential in differentiating C2C12 myoblasts by stimulating viability, calcium homeostasis and energy generation.The journal of physiological sciences : JPS · 2018Article
- Harnessing Sphingosine-1-Phosphate Signaling and Nanotopographical Cues To Regulate Skeletal Muscle Maturation and Vascularization.ACS nano · 2017Article
- The role of sphingolipid signalling in diabetes‑associated pathologies (Review).International journal of molecular medicine · 2017Review
- Dietary supplementation with bovine-derived milk fat globule membrane lipids promotes neuromuscular development in growing rats.Nutrition & metabolism · 2017Article
- Lysophospholipid receptor nomenclature review: IUPHAR Review 8.British journal of pharmacology · 2014Review
- Succinate dehydrogenase subunit B mutations modify human neuroblastoma cell metabolism and proliferation.Hormones & cancer · 2014Article
- Sphingosine phosphate lyase regulates myogenic differentiation via S1P receptor-mediated effects on myogenic microRNA expression.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy.Disease models & mechanisms · 2014Article
- Sphingosine 1-phosphate axis: a new leader actor in skeletal muscle biology.Frontiers in physiology · 2013Review
- Sphingosine-1-phosphate receptor 3 influences cell cycle progression in muscle satellite cells.Developmental biology · 2013Article
- Increased sphingosine-1-phosphate improves muscle regeneration in acutely injured mdx mice.Skeletal muscle · 2013Article
- Drosophila as a starting point for developing therapeutics for the rare disease Duchenne Muscular Dystrophy.Rare diseases (Austin, Tex.) · 2013Article
- Genetic elevation of sphingosine 1-phosphate suppresses dystrophic muscle phenotypes in Drosophila.Development (Cambridge, England) · 2013Article
- Article
- Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway.PloS one · 2012Article
- G-protein coupled receptors in stem cell self-renewal and differentiation.Stem cell reviews and reports · 2010Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of sphingosine 1-phosphate (S1P) on the proliferative response to low serum was examined in two closely related cell populations, such as C2C12 reserve cells and myoblasts. S1P reduced DNA synthesis promoted by serum in myoblasts, whereas it enhanced the mitogenic response to serum in reserve cells. By employing selective S1P receptor agonist and antagonists, the co-mitogenic action of S1P in reserve cells was shown to depend mainly on S1P(1). Real time PCR analysis revealed distinct S1P receptor pattern expression, which however could not account for the differential action of S1P in C2C12 reserve cells and myoblasts, thereby suggesting that the cell-specific responsiveness to S1P may depend on a different functional coupling of S1P(1). This study discloses a unique pleiotropic effect of S1P which stimulates proliferation of muscle resident stem cells, such as reserve cells, and favours the growth arrest of committed progenitors cells, such as myoblasts, required for their subsequent myogenic differentiation.
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