ArticleOncogene2008
Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coli.
Article in Oncogene, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Wnt-Independent and Wnt-Dependent Effects of APC Loss on the Chemotherapeutic Response.International journal of molecular sciences · 2020Review
- An update on guanylyl cyclase C in the diagnosis, chemoprevention, and treatment of colorectal cancer.Expert review of clinical pharmacology · 2020Review
- Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer.Genome medicine · 2020Article
- Infection with genotoxin-producing Salmonella enterica synergises with loss of the tumour suppressor APC in promoting genomic instability via the PI3K pathway in colonic epithelial cells.Cellular microbiology · 2019Article
- Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: implications for therapeutic targeting.Cancer metastasis reviews · 2018Review
- The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia.Frontiers in oncology · 2018Review
- Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer.Journal of the National Cancer Institute · 2017Review
- Nuclear α-catenin mediates the DNA damage response via β-catenin and nuclear actin.Journal of cell science · 2017Article
- Interaction between APC and Fen1 during breast carcinogenesis.DNA repair · 2016Review
- Apc regulates the function of hematopoietic stem cells largely through β-catenin-dependent mechanisms.Blood · 2013Article
- Identifying novel protein complexes in cancer cells using epitope-tagging of endogenous human genes and affinity-purification mass spectrometry.Journal of proteome research · 2012Article
- Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function.Neoplasia (New York, N.Y.) · 2012Article
- Adenomatous polyposis coli protein associates with C/EBP beta and increases Bacillus anthracis edema toxin-stimulated gene expression in macrophages.The Journal of biological chemistry · 2011Article
- Assembly of the base excision repair complex on abasic DNA and role of adenomatous polyposis coli on its functional activity.Biochemistry · 2011Article
- DNA polymerase β as a novel target for chemotherapeutic intervention of colorectal cancer.PloS one · 2011Article
- Tissue polarity-dependent control of mammary epithelial homeostasis and cancer development: an epigenetic perspective.Journal of mammary gland biology and neoplasia · 2010Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adenomatous polyposis coli (APC) is a tumor suppressor whose loss of function leads to colon cancer. APC shuttles between the nucleus and cytoplasm, however its role in the nucleus remains elusive. We have found that nuclear APC specifically associates with transcriptionally active chromatin through structural elements located downstream to the region of frequent truncation mutations found in colorectal tumors. We show that a recombinant APC fragment comprising such elements associates in vivo with euchromatin and preferentially binds in vitro to acetylated histone H3. Induction of DNA double-strand breaks (DSB) stimulates accumulation of APC at the damaged DNA chromatin marked by histone H2AX and S139-phosphorylated histone H2AX. A nuclear complex containing the DNA-dependent protein kinase catalytic subunit (DNAPKcs) and APC associates with chromatin in response to DNA DSB. APC knockdown with siRNA decreased the rate of DNA DSB-induced S139 histone H2AX phosphorylation in cells expressing endogenous full-length APC, but not in colon cancer cells with its truncation mutants, whereas ectopic APC expression stimulated the H2AX phosphorylation regardless of the type of endogenous APC. Our data suggest that APC involves in the DSB DNA repair and that truncation mutations impair chromatin-associated functions of APC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.