ArticleBritish journal of pharmacology2008
Rapamycin affects early fracture healing in mice.
Article in British journal of pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 67 citations in OpenAlex.
- Ageing, women's health and personalised medicine: Advancing artificial intelligence and therapeutics through the blueprint theory paradigm.Experimental physiology · 2026Article
- Tackling aging and chronic disease: How space exploration and the 'chameleon effect' of pharmaceuticals can lead the way.Experimental physiology · 2026Review
- Bench to bedside: is rapamycin headed for the docTOR?GeroScience · 2026Review
- Synergistic 3D-bioprinted scaffold with multi-level adaptability for vascularized bone regeneration via osteogenesis-angiogenesis coupling.Materials today. Bio · 2026Article
- Recent advancement in vascularized tissue-engineered bone based on materials design and modification.Materials today. Bio · 2023Review
- Callus γδ T cells and microbe-induced intestinal Th17 cells improve fracture healing in mice.The Journal of clinical investigation · 2023Article
- Review
- Motivating role of type H vessels in bone regeneration.Cell proliferation · 2020Review
- Local delivery of bone morphogenetic protein-2 from near infrared-responsive hydrogels for bone tissue regeneration.Biomaterials · 2020Article
- Does mammalian target of rapamycin or sestrin 1 protein signaling have a role in bone fracture healing?Turkish journal of medical sciences · 2019Article
- VEGFA From Early Osteoblast Lineage Cells (Osterix+) Is Required in Mice for Fracture Healing.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
- [Influence of frequently prescribed drugs on bone healing].Der Unfallchirurg · 2019Review
- Loss of Dnmt3b in Chondrocytes Leads to Delayed Endochondral Ossification and Fracture Repair.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Article
- Osteoimmunology in Bone Fracture Healing.Current osteoporosis reports · 2017Review
- Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.Nature reviews. Drug discovery · 2017Review
- Sildenafil Transiently Delays Early Alveolar Healing of Tooth Extraction Sockets.Clinics in surgery · 2017Article
- Energetic interventions for healthspan and resiliency with aging.Experimental gerontology · 2016Review
- Rapamycin-induced autophagy activity promotes bone fracture healing in rats.Experimental and therapeutic medicine · 2015Article
- The multifaceted role of the vasculature in endochondral fracture repair.Frontiers in endocrinology · 2015Review
- Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe immunosuppressive drug rapamycin (RAPA) prevents rejection in organ transplantation by inhibiting interleukin-2-stimulated T-cell division. Rapamycin has also been suggested to possess strong anti-angiogenic activities linked to a decrease in production of vascular endothelial growth factor (VEGF). Angiogenesis and VEGF are thought to play a crucial role in fracture healing and as osteoporotic and traumatic fractures are common complications in immunosuppressed, organ transplantation patients, we conducted this study to analyze the effect of rapamycin treatment on bone repair. EXPERIMENTAL APPROACH: We investigated the effect of rapamycin treatment on bone repair in a murine closed femur fracture model using radiological, histomorphometric, immunohistochemical, biomechanical and protein biochemical analyses. KEY
resultsX-ray analyses demonstrated that rapamycin treatment inhibits callus formation after two weeks of fracture healing. The radiologically observed lack of callus formation was confirmed by histomorphometric analyses, which revealed a significantly diminished callus size and a reduced amount of bone formation when compared with vehicle-treated controls. Biomechanical testing further demonstrated that rapamycin significantly reduces torsional stiffness of the callus. Interestingly, this effect was associated with decreased vessel formation; a diminished proliferation of osteoblasts, endothelial cells and periosteal cells; and a reduced VEGF expression in hypertrophic chondrocytes. After five weeks treatment, however, the negative impact of rapamycin on fracture healing was overcome. CONCLUSIONS AND IMPLICATIONS: Thus, rapamycin initially delays fracture healing, most probably by inhibiting cell proliferation and neovascularization in the callus. These undesirable effects should be considered when rapamycin is administered to patients sustaining bone fractures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.