ArticleActa crystallographica. Section F, Structural biology and crystallization communications2008
Structures of an alanine racemase from Bacillus anthracis (BA0252) in the presence and absence of (R)-1-aminoethylphosphonic acid (L-Ala-P).
Article in Acta crystallographica. Section F, Structural biology and crystallization communications, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 21 citations in OpenAlex.
- Structural Basis for the Catalysis and Substrate Specificity of a LarA Racemase with a Broad Substrate Spectrum.ACS catalysis · 2025Article
- Exploring the reaction dynamics of alanine racemase using serial femtosecond crystallography.Scientific reports · 2024Article
- Article
- Structural and biochemical analyses of alanine racemase from the multidrug-resistant Clostridium difficile strain 630.Acta crystallographica. Section D, Biological crystallography · 2014Article
- Crystallization and preliminary X-ray study of a thermostable alanine racemase from Thermoanaerobacter tengcongensis MB4.Acta crystallographica. Section F, Structural biology and crystallization communications · 2013Article
- Crystallization and preliminary X-ray diffraction analysis of alanine racemase from Pseudomonas putida YZ-26.Acta crystallographica. Section F, Structural biology and crystallization communications · 2012Article
- Structural features and kinetic characterization of alanine racemase from Staphylococcus aureus (Mu50).Acta crystallographica. Section D, Biological crystallography · 2012Article
- Crystal structures of lysine-preferred racemases, the non-antibiotic selectable markers for transgenic plants.PloS one · 2012Article
- The crystal structure of alanine racemase from Streptococcus pneumoniae, a target for structure-based drug design.BMC microbiology · 2011Article
- (R)-(1-Ammonio-eth-yl)phospho-nate.Acta crystallographica. Section E, Structure reports online · 2010Article
- Structure of the Escherichia coli RNA polymerase alpha subunit C-terminal domain.Acta crystallographica. Section D, Biological crystallography · 2010Article
- Biochemical and structural characterization of alanine racemase from Bacillus anthracis (Ames).BMC structural biology · 2009Article
- The spore-specific alanine racemase of Bacillus anthracis and its role in suppressing germination during spore development.Journal of bacteriology · 2009Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Bacillus anthracis, the causative agent of anthrax, has been targeted by the Oxford Protein Production Facility to validate high-throughput protocols within the Structural Proteomics in Europe project. As part of this work, the structures of an alanine racemase (BA0252) in the presence and absence of the inhibitor (R)-1-aminoethylphosphonic acid (L-Ala-P) have determined by X-ray crystallography to resolutions of 2.1 and 1.47 A, respectively. Difficulties in crystallizing this protein were overcome by the use of reductive methylation. Alanine racemase has attracted much interest as a possible target for anti-anthrax drugs: not only is D-alanine a vital component of the bacterial cell wall, but recent studies also indicate that alanine racemase, which is accessible in the exosporium, plays a key role in inhibition of germination in B. anthracis. These structures confirm the binding mode of L-Ala-P but suggest an unexpected mechanism of inhibition of alanine racemase by this compound and could provide a basis for the design of improved alanine racemase inhibitors with potential as anti-anthrax therapies.
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