ArticleJournal of immunology (Baltimore, Md. : 1950)2008
Functional Th1 cells are required for surgical adhesion formation in a murine model.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Prevention of adhesive small bowel obstruction by anti-adhesion barriers: do they really work?Techniques in coloproctology · 2026Review
- Preventive role of CD163-positive macrophages in postoperative peritoneal adhesions.Inflammation and regeneration · 2025Article
- Comparison of the effect of Everolimus, Prednisolone, and a combination of both on experimentally induced peritoneal adhesions in rats.Scientific reports · 2024Article
- Farnesol remodels the peritoneal cavity immune environment influencingInfection and immunity · 2023Article
- Transition of lymphocyte subsets in peritoneal dialysis effluent and its relationship to peritoneal damage.Journal of rural medicine : JRM · 2021Article
- Post-Operative Adhesions: A Comprehensive Review of Mechanisms.Biomedicines · 2021Review
- Prevention of Post-Operative Adhesions: A Comprehensive Review of Present and Emerging Strategies.Biomolecules · 2021Review
- Effect of ligustrazine nanoparticles on Th1/Th2 balance by TLR4/MyD88/NF-κB pathway in rats with postoperative peritoneal adhesion.BMC surgery · 2021Article
- A review of physiological and cellular mechanisms underlying fibrotic postoperative adhesion.International journal of biological sciences · 2021Review
- Pharmacological HIF-inhibition attenuates postoperative adhesion formation.Scientific reports · 2017Article
- The effects of pirfenidone on T helper cells in prevention of intraperitoneal adhesions.The Kaohsiung journal of medical sciences · 2017Article
- An injured tissue affects the opposite intact peritoneum during postoperative adhesion formation.Scientific reports · 2015Article
- Paricalcitol reduces peritoneal fibrosis in mice through the activation of regulatory T cells and reduction in IL-17 production.PloS one · 2014Article
- Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease.American journal of physiology. Gastrointestinal and liver physiology · 2012Review
- Comprehensive analysis of chemokines and cytokines secreted in the peritoneal cavity during laparotomy.Journal of immunoassay & immunochemistry · 2012Article
- Chronological evaluation of inflammatory mediators during peritoneal adhesion formation using a rat model.Langenbeck's archives of surgery · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Tissue trauma in the peritoneal and pelvic cavities following surgery or bacterial infection results in adhesions that are a debilitating cause of intestinal obstruction, chronic pelvic pain, and infertility in women. We recently demonstrated that CD4(+) alphabeta T cells are essential for development of this process. Using a murine model of experimental adhesion formation, we now demonstrate that adhesion formation is characterized by the selective recruitment of Tim-3(+), CCR5(+), CXCR3(+), IFN-gamma(+) cells, indicating the presence of a Th1 phenotype. We further demonstrate that adhesion formation is critically dependent on the function of Th1 cells because mice genetically deficient for IFN-gamma, T-bet, or treated with Abs to the Th1-selective chemoattractant IL-16 show significantly less adhesion formation than wild-type mice. In addition, disrupting the interaction of the Th1-specific regulatory molecule Tim-3, with its ligand, significantly exacerbates adhesion formation. This enhanced response is associated with increases in the level of neutrophil-attracting chemokines KC and MIP-2, known to play a role in adhesiogenesis. These data demonstrate that the CD4(+) T cells orchestrating adhesion formation are of the Th1 phenotype and delineate the central role of T-bet, Tim-3, IFN-gamma, and IL-16 in mediating this pathogenic tissue response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.