ArticleJournal of immunology (Baltimore, Md. : 1950)2008
Actin-binding protein 1 regulates B cell receptor-mediated antigen processing and presentation in response to B cell receptor activation.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 53 citations in OpenAlex.
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- Endophilin A2 regulates B-cell endocytosis and is required for germinal center and humoral responses.EMBO reports · 2021Article
- B Cells Adapt Their Nuclear Morphology to Organize the Immune Synapse and Facilitate Antigen Extraction.Frontiers in immunology · 2021Article
- STING couples with PI3K to regulate actin reorganization during BCR activation.Science advances · 2020Article
- The regulators of BCR signaling during B cell activation.Blood science (Baltimore, Md.) · 2019Review
- Role of Drebrin at the Immunological Synapse.Advances in experimental medicine and biology · 2017Review
- Transgelin-2 in B-Cells Controls T-Cell Activation by Stabilizing T Cell - B Cell Conjugates.PloS one · 2016Article
- Chorein addiction in VPS13A overexpressing rhabdomyosarcoma cells.Oncotarget · 2015Article
- Actin-binding protein 1 links B-cell antigen receptors to negative signaling pathways.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Phosphosite mapping of HIP-55 protein in mammalian cells.International journal of molecular sciences · 2014Article
- The pivotal position of the actin cytoskeleton in the initiation and regulation of B cell receptor activation.Biochimica et biophysica acta · 2014Review
- Actin-mediated feedback loops in B-cell receptor signaling.Immunological reviews · 2013Review
- Article
- The actin cytoskeleton coordinates the signal transduction and antigen processing functions of the B cell antigen receptor.Frontiers in biology · 2013Article
- How B cells capture, process and present antigens: a crucial role for cell polarity.Nature reviews. Immunology · 2013Review
- Regulation of late endosomal/lysosomal maturation and trafficking by cortactin affects Golgi morphology.Cytoskeleton (Hoboken, N.J.) · 2012Article
- Src-mediated phosphorylation of mammalian Abp1 (DBNL) regulates podosome rosette formation in transformed fibroblasts.Journal of cell science · 2012Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The BCR serves as both signal transducer and Ag transporter. Binding of Ags to the BCR induces signaling cascades and Ag processing and presentation, two essential cellular events for B cell activation. BCR-initiated signaling increases BCR-mediated Ag-processing efficiency by increasing the rate and specificity of Ag transport. Previous studies showed a critical role for the actin cytoskeleton in these two processes. In this study, we found that actin-binding protein 1 (Abp1/HIP-55/SH3P7) functioned as an actin-binding adaptor protein, coupling BCR signaling and Ag-processing pathways with the actin cytoskeleton. Gene knockout of Abp1 and overexpression of the Src homology 3 domain of Abp1 inhibited BCR-mediated Ag internalization, consequently reducing the rate of Ag transport to processing compartments and the efficiency of BCR-mediated Ag processing and presentation. BCR activation induced tyrosine phosphorylation of Abp1 and translocation of both Abp1 and dynamin 2 from the cytoplasm to plasma membrane, where they colocalized with the BCR and cortical F-actin. Mutations of the two tyrosine phosphorylation sites of Abp1 and depolymerization of the actin cytoskeleton interfered with BCR-induced Abp1 recruitment to the plasma membrane. The inhibitory effect of a dynamin proline-rich domain deletion mutant on the recruitment of Abp1 to the plasma membrane, coimmunoprecipitation of dynamin with Abp1, and coprecipitation of Abp1 with GST fusion of the dyanmin proline-rich domain demonstrate the interaction of Abp1 with dynamin 2. These results demonstrate that the BCR regulates the function of Abp1 by inducing Abp1 phosphorylation and actin cytoskeleton rearrangement, and that Abp1 facilitates BCR-mediated Ag processing by simultaneously interacting with dynamin and the actin cytoskeleton.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.