ArticleJournal of neuroscience methods2008
The virtual slice setup.
Article in Journal of neuroscience methods, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Simulation Neurotechnologies for Advancing Brain Research: Parallelizing Large Networks in NEURON.Neural computation · 2016Article
- Restoring Behavior via Inverse Neurocontroller in a Lesioned Cortical Spiking Model Driving a Virtual Arm.Frontiers in neuroscience · 2016Article
- Cortical Spiking Network Interfaced with Virtual Musculoskeletal Arm and Robotic Arm.Frontiers in neurorobotics · 2015Article
- Motor cortex microcircuit simulation based on brain activity mapping.Neural computation · 2014Article
- Towards a real-time interface between a biomimetic model of sensorimotor cortex and a robotic arm.Pattern recognition letters · 2014Article
- Reinforcement learning of two-joint virtual arm reaching in a computer model of sensorimotor cortex.Neural computation · 2013Article
- Cortical information flow in Parkinson's disease: a composite network/field model.Frontiers in computational neuroscience · 2013Article
- Reinforcement learning of targeted movement in a spiking neuronal model of motor cortex.PloS one · 2012Article
- Synaptic information transfer in computer models of neocortical columns.Journal of computational neuroscience · 2011Article
- Emergence of physiological oscillation frequencies in a computer model of neocortex.Frontiers in computational neuroscience · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In an effort to design a simulation environment that is more similar to that of neurophysiology, we introduce a virtual slice setup in the NEURON simulator. The virtual slice setup runs continuously and permits parameter changes, including changes to synaptic weights and time course and to intrinsic cell properties. The virtual slice setup permits shocks to be applied at chosen locations and activity to be sampled intra- or extracellularly from chosen locations. By default, a summed population display is shown during a run to indicate the level of activity and no states are saved. Simulations can run for hours of model time, therefore it is not practical to save all of the state variables. These, in any case, are primarily of interest at discrete times when experiments are being run: the simulation can be stopped momentarily at such times to save activity patterns. The virtual slice setup maintains an automated notebook showing shocks and parameter changes as well as user comments. We demonstrate how interaction with a continuously running simulation encourages experimental prototyping and can suggest additional dynamical features such as ligand wash-in and wash-out-alternatives to typical instantaneous parameter change. The virtual slice setup currently uses event-driven cells and runs at approximately 2 min/h on a laptop.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.