ArticleMechanisms of ageing and development
Trade-off between cancer and aging: what role do other diseases play? Evidence from experimental and human population studies.
Article in Mechanisms of ageing and development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- The Construction of a Multidomain Risk Model of Alzheimer's Disease and Related Dementias.Journal of Alzheimer's disease : JAD · 2023Article
- Towards a Consensus on Alzheimer's Disease Comorbidity?Journal of clinical medicine · 2021Review
- Lifespan Extension in Long-Lived Vertebrates Rooted in Ecological Adaptation.Frontiers in cell and developmental biology · 2021Review
- Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses.Experimental gerontology · 2018Article
- Puzzling role of genetic risk factors in human longevity: "risk alleles" as pro-longevity variants.Biogerontology · 2016Review
- How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.Biogerontology · 2016Review
- Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.Annals of epidemiology · 2015Article
- Morbidity risks among older adults with pre-existing age-related diseases.Experimental gerontology · 2013Article
- Unraveling genetic origin of aging-related traits: evolving concepts.Rejuvenation research · 2013Review
- Early life exposure to the 1918 influenza pandemic and old-age mortality by cause of death.American journal of public health · 2013Article
- Cancer and longevity--is there a trade-off? A study of cooccurrence in Danish twin pairs born 1900-1918.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
- Chronic Diseases among Older Cancer Survivors.Journal of cancer epidemiology · 2012Article
- A unifying framework for assessing changes in life expectancy associated with changes in mortality: the case of violent deaths.Theoretical population biology · 2011Review
- Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth.Mechanisms of ageing and development · 2011Article
- Impaired orthotopic glioma growth and vascularization in transgenic mouse models of Alzheimer's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Trade-offs between cancer and other diseases: do they exist and influence longevity?Rejuvenation research · 2010Article
- Chronic disease in men with newly diagnosed cancer: a nested case-control study.American journal of epidemiology · 2010Article
- Parents' ages at birth and risk of adult-onset hematologic malignancies among female teachers in California.American journal of epidemiology · 2010Article
- Anti-Tumoral Activity of a Short Decapeptide Fragment of the Alzheimer's Abeta Peptide.International journal of peptide research and therapeutics · 2010Article
- Stroke in cancer patients: a risk factor analysis.Journal of neuro-oncology · 2009Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The potential gain in life expectancy which could result from the complete elimination of mortality from cancer in the U.S. would not exceed 3 years if one were to consider cancer independently of other causes of death. In this paper, we review evidence of trade-offs between cancer and aging as well as between cancer and other diseases, which, if taken into account, may substantially increase estimates of gain in life expectancy resulting from cancer eradication. We also used the Multiple Causes of Death (MCD) data to evaluate correlations among mortalities from cancer and other major disorders including heart disease, stroke, diabetes, Alzheimer's, Parkinson's diseases, and asthma. Our analyses revealed significant negative correlations between cancer and other diseases suggesting stronger population effects of cancer eradication. Possible mechanisms of the observed dependencies and emerging perspectives of using dependent competing risks models for evaluating the effects of reduction of mortality from cancer on life expectancy are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.