ArticleArchives of physical medicine and rehabilitation2008
Impact of age on long-term recovery from traumatic brain injury.
Article in Archives of physical medicine and rehabilitation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
73 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Functional recovery in older adults following mild traumatic brain injury: a systematic review.European geriatric medicine · 2026Pooled it
- Drivers of resting-state fMRI heterogeneity in traumatic brain injury across injury characteristics and imaging methods: a systematic review and semiquantitative analysis.Frontiers in neurology · 2024Pooled it
- Characteristics and Impact of U.S. Military Blast-Related Mild Traumatic Brain Injury: A Systematic Review.Frontiers in neurology · 2020Pooled it
- The Effects of Moderate-to-Severe Traumatic Brain Injury on Episodic Memory: a Meta-Analysis.Neuropsychology review · 2019Pooled it
- Early trajectory of psychiatric symptoms after traumatic brain injury: relationship to patient and injury characteristics.Journal of neurotrauma · 2014Trial
- Long-term cognitive and psychological outcomes in the awakening and breathing controlled trial.American journal of respiratory and critical care medicine · 2010Trial
- Timing of neurorehabilitation and subsequent Alzheimer's disease risk in patients with moderate to severe traumatic brain injury: A nationwide retrospective cohort study in the United States.Journal of Alzheimer's disease : JAD · 2025Article
- Advances and challenges in experimental models of posttraumatic epilepsy for therapeutic interventions.Pharmacological reviews · 2025Review
- Aging Effects on Lipid Metabolism in Response to Traumatic Brain Injury.Journal of neurochemistry · 2025Article
- Hospital experience with geriatric trauma impacts long-term survival.American journal of surgery · 2025Article
- Changes in the neurological status from 30 to 90 days post-cardiac arrest by age: A nationwide retrospective observational study.Resuscitation plus · 2025Article
- Unilateral biportal endoscopy-induced intracranial pneumocephalus as radiographic evidence of raised intracranial pressure resulting from dural tear: a case report.Frontiers in surgery · 2025Article
- Effectiveness of Transcranial Direct Current Stimulation on Cognitive Function: A Pilot Study.Medical journal of the Islamic Republic of Iran · 2025Article
- The Impact of the Pandemic of COVID-19 on the Head Injury Fast-Track System and Surgical Outcome.Asian journal of neurosurgery · 2024Article
- Long-term outcome of traumatic brain injury patients with initial GCS of 3-5.World neurosurgery: X · 2024Article
- Modeling of the brain-lung axis using organoids in traumatic brain injury: an updated review.Cell & bioscience · 2024Review
- Article
- Age at Injury as a Modifier of Preclinical TBI Behavioral, Neuropathological, and Inflammatory Outcomes.Advances in neurobiology · 2024Review
- Chronic Stress in Early Development and Effects on Traumatic Brain Injury Outcome.Advances in neurobiology · 2024Review
- Time-dependent homeostatic mechanisms underlie brain-derived neurotrophic factor action on neural circuitry.Communications biology · 2023Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectiveTo determine whether older persons are at increased risk for progressive functional decline after traumatic brain injury (TBI).
designLongitudinal cohort study.
settingTraumatic Brain Injury Model Systems (TBIMS) rehabilitation centers.
participantsSubjects enrolled in the TBIMS national dataset.
interventionsNot applicable.
main outcome measuresDisability Rating Scale (DRS), FIM instrument cognitive items, and the Glasgow Outcome Scale-Extended.
resultsParticipants were separated into 3 age tertiles: youngest (16-26y), intermediate (27-39y), and oldest (> or =40y). DRS scores were comparable across age groups at admission to a rehabilitation center. The oldest group was slightly more disabled at discharge from rehabilitation despite having less severe acute injury severity than the younger groups. Although DRS scores for the 2 younger groups improved significantly from year 1 to year 5, the greatest magnitude of improvement in disability was seen among the youngest group. In addition, after dividing patients into groups according to whether their DRS scores improved (13%), declined (10%), or remained stable (77%) over time, the likelihood of decline was found to be greater for the 2 older groups than for the youngest group. A multiple regression model showed that age has a significant negative influence on DRS score 5 years post-TBI after accounting for the effects of covariates.
conclusionsThis study supported our primary hypothesis that older patients show greater decline over the first 5 years after TBI than younger patients. In addition, the greatest amount of improvement in disability was observed among the youngest group of survivors. These results suggest that TBI survivors, especially older patients, may be candidates for neuroprotective therapies after TBI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.