ArticleThe Journal of clinical investigation2008
Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice.
Article in The Journal of clinical investigation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed.
- Review
- Diversity of Circulating NKT Cells in Defense against Carbapenem-Resistant Klebsiella Pneumoniae Infection.Journal of personalized medicine · 2022Article
- Mitochondrial metabolism is essential for invariant natural killer T cell development and function.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells.Cellular & molecular immunology · 2021Review
- Article
- Nur77 controls tolerance induction, terminal differentiation, and effector functions in semi-invariant natural killer T cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Natural Killer T Cells Are Numerically and Functionally Deficient in Patients with Trauma.Journal of innate immunity · 2020Article
- Type II Natural Killer T Cells Contribute to Protection Against Systemic Methicillin-ResistantFrontiers in immunology · 2020Article
- Modulation of Immune Responses to Influenza A Virus Vaccines by Natural Killer T Cells.Frontiers in immunology · 2020Review
- Psychopharmacology: neuroimmune signaling in psychiatric disease-developing vaccines against abused drugs using toll-like receptor agonists.Psychopharmacology · 2019Review
- Activation of natural killer T cells contributes to triptolide-induced liver injury in mice.Acta pharmacologica Sinica · 2018Article
- The Role of Natural Killer T Cells in Cancer-A Phenotypical and Functional Approach.Frontiers in immunology · 2018Review
- Article
- Role of NK, NKT cells and macrophages in liver transplantation.World journal of gastroenterology · 2016Review
- Selective Conditions Are Required for the Induction of Invariant NKT Cell Hyporesponsiveness by Antigenic Stimulation.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- The Response of CD1d-Restricted Invariant NKT Cells to Microbial Pathogens and Their Products.Frontiers in immunology · 2015Review
- Invariant NKT cell response to dengue virus infection in human.PLoS neglected tropical diseases · 2014Article
- Article
- Exosome-like nanoparticles from intestinal mucosal cells carry prostaglandin E2 and suppress activation of liver NKT cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Turned on by danger: activation of CD1d-restricted invariant natural killer T cells.Immunology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Invariant NKT (iNKT) cells are innate-like lymphocytes that recognize glycolipid antigens in the context of the MHC class I-like antigen-presenting molecule CD1d. In vivo activation of mouse iNKT cells with the glycolipid alpha-galactosylceramide (alpha-GalCer) results in the acquisition of a hyporesponsive (anergic) phenotype by these cells. Because iNKT cells can become activated in the context of infectious agents, here we evaluated whether iNKT cell activation by microorganisms can influence subsequent responses of these cells to glycolipid antigen stimulation. We found that mouse iNKT cells activated in vivo by multiple bacterial microorganisms, or by bacterial LPS or flagellin, became unresponsive to subsequent activation with alpha-GalCer. This hyporesponsive phenotype of iNKT cells required IL-12 expression and was associated with changes in the surface phenotype of these cells, reduced severity of concanavalin A-induced hepatitis, and alterations in the therapeutic activities of alpha-GalCer. These findings may have important implications for the development of iNKT cell-based therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.