ArticleEMBO reports2008
A transcription cofactor required for the heat-shock response.
Article in EMBO reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 68 citations in OpenAlex.
- Integrating pharmacokinetics and network pharmacology to decipher the efficacy of Fufang Qinlan oral liquid on post infectious cough.Journal of traditional and complementary medicine · 2025Article
- Long-read genome assemblies reveal aZoological research · 2023Article
- HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.Nature communications · 2022Article
- Evaluation of the Role of p53 Tumour Suppressor Posttranslational Modifications and TTC5 Cofactor in Lung Cancer.International journal of molecular sciences · 2021Article
- Oxidative stress induces Ser 2 dephosphorylation of the RNA polymerase II CTD and premature transcription termination.Transcription · 2021Article
- Generation of GCaMP6s-Expressing Zebrafish to Monitor Spatiotemporal Dynamics of Calcium Signaling Elicited by Heat Stress.International journal of molecular sciences · 2021Article
- Gaining new insights on the Hsp90 regulatory network.Bioinformation · 2020Article
- RNF20/40-mediated eEF1BδL monoubiquitylation stimulates transcription of heat shock-responsive genes.Nucleic acids research · 2019Article
- Receptor-interacting protein 140 as a co-repressor of Heat Shock Factor 1 regulates neuronal stress response.Cell death & disease · 2017Article
- Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock.Scientific reports · 2017Article
- Regulatory Mechanisms of Hsp90.Biochemistry & molecular biology journal · 2017Article
- Mechanisms of Hsp90 regulation.The Biochemical journal · 2016Review
- Requirement for endogenous heat shock factor 1 in inducible nitric oxide synthase induction in murine microglia.Journal of neuroinflammation · 2015Article
- Genetic polymorphisms within exon 3 of heat shock protein 90AA1 gene and its association with heat tolerance traits in Sahiwal cows.Veterinary world · 2015Article
- ATF1 modulates the heat shock response by regulating the stress-inducible heat shock factor 1 transcription complex.Molecular and cellular biology · 2015Article
- The conserved PBAF nucleosome-remodeling complex mediates the response to stress in Caenorhabditis elegans.Molecular and cellular biology · 2014Article
- TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells.Cell death & disease · 2013Article
- Molecular cochaperones: tumor growth and cancer treatment.Scientifica · 2013Review
- Heat shock factor-1 intertwines insulin/IGF-1, TGF-β and cGMP signaling to control development and aging.BMC developmental biology · 2012Article
- Basal and stress-induced Hsp70 are modulated by ataxin-3.Cell stress & chaperones · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The Stress-responsive activator of p300 (Strap) is a transcription cofactor that has an important role in the control of DNA damage response through its ability to regulate p53 activity. Here, we report that Strap is inducible by heat shock and stimulates the transcription of heat-shock genes. A chromatin-associated complex involving heat-shock factor 1 (HSF1), Strap and the p300 coactivator assembles on the heat-shock protein 70 (hsp70) promoter, and Strap augments HSF1 binding and chromatin acetylation in Hsp genes, most probably through the p300 histone acetyltransferase. Cells depleted of Strap do not survive under heat-shock conditions. These results indicate that Strap is an essential cofactor that acts at the level of chromatin control to regulate heat-shock-responsive transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.