ArticleArteriosclerosis, thrombosis, and vascular biology2008
Polymorphisms of the IL1-receptor antagonist gene (IL1RN) are associated with multiple markers of systemic inflammation.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts.Circulation. Cardiovascular genetics · 2009Pooled it
- A functional synonymous coding variant in the IL1RN gene is associated with survival in septic shock.American journal of respiratory and critical care medicine · 2014Trial
- Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes.Diabetes care · 2009Trial
- Association of Interleukin 1 Receptor Antagonist (International journal of molecular sciences · 2026Article
- Precision Medicine in Orthobiologics: A Paradigm Shift in Regenerative Therapies.Bioengineering (Basel, Switzerland) · 2025Review
- Longitudinal analysis of genetic and environmental interplay in human metabolic profiles and the implication for metabolic health.Genome medicine · 2025Article
- Identification of progression related LncRNAs in colorectal cancer aggressiveness.Scientific reports · 2025Article
- Traditional Chinese Medicine in the Comprehensive Management of Tourette Syndrome: Insights from Genetics and Pathophysiology: A Review.Drug design, development and therapy · 2025Review
- Interleukin-1 Receptor Antagonist Gene (IL1RN) Variants Modulate the Cytokine Release Syndrome and Mortality of COVID-19.The Journal of infectious diseases · 2024Article
- Genome-wide association study of circulating interleukin 6 levels identifies novel loci.Human molecular genetics · 2021Article
- Interleukin 1 receptor antagonist gene variable number of tandem repeats polymorphism and cutaneous melanoma.Oncology letters · 2019Article
- Inflammation-Accelerated Senescence and the Cardiovascular System: Mechanisms and Perspectives.International journal of molecular sciences · 2018Review
- Association of a genetic polymorphism of IL1RN with risk of acute pancreatitis in a Korean ethnic group.The Korean journal of internal medicine · 2018Article
- Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty.Nature reviews. Cardiology · 2018Review
- Polymorphisms in inflammation-related genes and the risk of primary varicose veins in ethnic Russians.Immunologic research · 2018Article
- Inflammation and the Silent Sequelae of Stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Loss of Interleukin 1 Receptor Antagonist Enhances Susceptibility to Ebola Virus Infection.The Journal of infectious diseases · 2015Article
- Genetic epidemiology of coronary artery disease: an Asian Indian perspective.Journal of genetics · 2015Review
- Poststroke fatigue: hints to a biological mechanism.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2015Article
- Exploratory Cohort Study of Associations between Serum C - Reactive Protein and Fatigue after Stroke.PloS one · 2015Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundCirculating levels of acute phase reactant proteins such as plasma C-reactive protein (CRP) are likely influenced by multiple genes regulating the innate immune response. METHODS AND
resultsWe screened a set of 16 inflammation-related genes for association with CRP in a large population-based study of healthy young adults (n=1627). Results were validated in 2 independent studies (n=1208 and n=4310), including a pooled analysis of all 3 studies. In the pooled analysis, the minor allele of IL1RN 1018 (rs4251961) within the gene encoding interleukin (IL)-1 receptor antagonist (IL-1RA) was significantly associated with higher mean plasma log(CRP) level (P<1 x 10(-4)). The same IL1RN 1018 allele was associated with higher mean plasma log(IL-6) levels (P=0.004). In the pooled analysis, the minor allele of IL1RN 13888 (rs2232354) was associated with higher fibrinogen, (P=0.001). The IL1RN 1018 and 13888 variant alleles tag a clade of IL1RN haplotypes linked to allele 1 of an 86-bp VNTR polymorphism. We confirmed that the IL1RN 1018 variant (rs4251961) was associated with decreased cellular IL-1RA production ex vivo.
conclusionsCommon functional polymorphisms of the IL1RN gene are associated with several markers of systemic inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.