ArticlePlant physiology2008
Characterization and biological function of the ISOCHORISMATE SYNTHASE2 gene of Arabidopsis.
Article in Plant physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 172 papers.
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Who cites it
172 citing papers in PubMed, 407 citations in OpenAlex.
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- Metabolite-mediated plant immunity: From traditional defenders to artificial elicitors.Journal of integrative plant biology · 2026Review
- Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026Review
- Benzyl alcohol biosynthesis and its subcellular compartmentalization enable scent formation and salicylic acid production.Nature communications · 2026Article
- From signals to solutions: stress-induced leaf senescence and synthetic biology and AI approaches for crop resilience.Molecular horticulture · 2026Review
- Genome-Wide Identification and Characterization of the Key Genes for Salicylic Acid Biosynthesis in Four Cotton Species.International journal of molecular sciences · 2026Article
- Salicylic acid: a key natural foundation for next-generation plant defense stimulators.Pest management science · 2026Review
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- Exploring the Functional Roles of Endophytic Bacteria in Plant Stress Tolerance for Sustainable Agriculture: Diversity, Mechanisms, Applications, and Challenges.Plants (Basel, Switzerland) · 2026Review
- A biosynthetic gene cluster for three post-chorismate pathways in Arabidopsis.Nature plants · 2026Article
- Discovery of a defence-response gene forFrontiers in plant science · 2026Article
- Salicylic acid signaling controls the colonization behavior ofFrontiers in plant science · 2026Article
- Grapevine LysM-containing receptor-like kinaseFrontiers in plant science · 2026Article
- Salicylic acid biosynthesis via the PAL pathway requires benzaldehyde synthase and a benzyl salicylate-specific esterase.The Plant cell · 2025Article
- Living with temperature changes: Salicylic acid at the crossroads of plant immunity and temperature resilience.Science advances · 2025Review
- Genetic suppressors of the growth-immunity trade-off in the Arabidopsis salicylic acid-accumulating dmr6 dlo1 mutant.The Plant journal : for cell and molecular biology · 2025Article
- Article
- Emergence of isochorismate-based salicylic acid biosynthesis within Brassicales.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- BAF60/SWP73 subunits define subclasses of SWI/SNF chromatin remodelling complexes in Arabidopsis.The New phytologist · 2025Article
112 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salicylic acid (SA) is an important mediator of plant defense response. In Arabidopsis (Arabidopsis thaliana), this compound was proposed to derive mainly from isochorismate, itself produced from chorismate through the activity of ISOCHORISMATE SYNTHASE1 (ICS1). Null ics1 mutants still accumulate some SA, suggesting the existence of an enzymatic activity redundant with ICS1 or of an alternative ICS-independent SA biosynthetic route. Here, we studied the role of ICS2, a second ICS gene of the Arabidopsis genome, in the production of SA. We have shown that ICS2 encodes a functional ICS enzyme and that, similar to ICS1, ICS2 is targeted to the plastids. Comparison of SA accumulation in the ics1, ics2, and ics1 ics2 mutants indicates that ICS2 participates in the synthesis of SA, but in limited amounts that become clearly detectable only when ICS1 is lacking. This unequal redundancy relationship was also observed for phylloquinone, another isochorismate-derived end product. Furthermore, detection of SA in the double ics1 ics2 double mutant that is completely devoid of phylloquinone provides genetic evidence of the existence of an ICS-independent SA biosynthetic pathway in Arabidopsis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.