ArticleCancer research2008
Androgens transduce the G alphas-mediated activation of protein kinase A in prostate cells.
Article in Cancer research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- The importance of protein kinase A in prostate cancer: relationship to patient outcome in Radiation Therapy Oncology Group trial 92-02.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Trial
- Revisiting the roles of cAMP signalling in the progression of prostate cancer.The Biochemical journal · 2023Article
- Article
- The Effects of Androgens on Cardiometabolic Syndrome: Current Therapeutic Concepts.Sexual medicine · 2020Review
- Activation of GPR56, a novel adhesion GPCR, is necessary for nuclear androgen receptor signaling in prostate cells.PloS one · 2020Article
- The Effects of Androgens on T Cells: Clues to Female Predominance in Autoimmune Liver Diseases?Frontiers in immunology · 2020Review
- Phosphorylation of HSP90 by protein kinase A is essential for the nuclear translocation of androgen receptor.The Journal of biological chemistry · 2019Article
- Role of androgens in cardiovascular pathology.Vascular health and risk management · 2018Review
- Androgen actions on endothelium functions and cardiovascular diseases.Journal of geriatric cardiology : JGC · 2016Review
- Enhanced inhibition of prostate tumor growth by dual targeting the androgen receptor and the regulatory subunit type iα of protein kinase a in vivo.International journal of molecular sciences · 2013Article
- Article
- Trenbolone enhances myogenic differentiation by enhancing β-catenin signaling in muscle-derived stem cells of cattle.Domestic animal endocrinology · 2011Article
- Minireview: Extranuclear steroid receptors: roles in modulation of cell functions.Molecular endocrinology (Baltimore, Md.) · 2011Review
- Phosphodiesterase 11A (PDE11A) genetic variants may increase susceptibility to prostatic cancer.The Journal of clinical endocrinology and metabolism · 2011Article
- Identification of betaArrestin2 as a corepressor of androgen receptor signaling in prostate cancer.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway.Cancer research · 2009Article
- 2,2-bis(4-chlorophenyl)-1,1-dichloroethylene stimulates androgen independence in prostate cancer cells through combinatorial activation of mutant androgen receptor and mitogen-activated protein kinase pathways.Molecular cancer research : MCR · 2008Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Androgens regulate the development and function of male reproductive organs and play a crucial role in the onset and progression of prostate cancer. Androgen action is primarily mediated through the nuclear androgen receptor (AR) which acts as a ligand-dependent transcription factor. This mode of androgen action takes hours to manifest and is called the genomic pathway. The androgen-mediated genomic responses require activity of cyclic AMP (cAMP)-dependent protein kinase (PKA). Androgens also act through nongenomic pathways in certain cell types to evoke rapid responses (manifested in minutes) that are mediated through changes in ion currents and second messengers. Here, we show that androgen causes the rapid and cAMP-dependent activation of PKA in prostate cells. The androgen-induced PKA activation is not inhibited by nuclear AR antagonist bicalutamide and can be observed in cells that do not express nuclear AR gene. Reduction of G alphas expression with siRNA attenuates the androgen-mediated activation of PKA, which is required for the androgen-induced prostate cell proliferation. We conclude that androgen actively evokes a nongenomic signaling pathway to activate PKA that is needed for the genomic functioning of nuclear AR. The inhibition of PKA activation, together with standard AR-targeted therapies, may be more efficacious for treatment of patients with prostate cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.