ArticleEndocrinology2008
Role and regulation of adipokines during zymosan-induced peritoneal inflammation in mice.
Article in Endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Hidden attributes of zymosan in the pathogenesis of inflammatory diseases: A tale of the fungal agent.Iranian journal of basic medical sciences · 2023Review
- Article
- Effects of Lentinula edodes consumption on biochemical, hematologic and oxidative stress parameters in rats receiving high-fat diet.European journal of nutrition · 2017Article
- Resistin deficiency in mice has no effect on pulmonary responses induced by acute ozone exposure.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Adipose tissue dendritic cells enhances inflammation by prompting the generation of Th17 cells.PloS one · 2014Article
- Genetic deficiency of adiponectin protects against acute kidney injury.Kidney international · 2013Article
- Neutrophil recruitment and function in health and inflammation.Nature reviews. Immunology · 2013Review
- Article
- Obesity is associated with neutrophil dysfunction and attenuation of murine acute lung injury.American journal of respiratory cell and molecular biology · 2012Article
- Role of IL-6 in the resolution of pancreatitis in obese mice.Journal of leukocyte biology · 2012Article
- Clinical review: adiponectin biology and its role in inflammation and critical illness.Critical care (London, England) · 2011Review
- IL-17 in obesity and adipogenesis.Cytokine & growth factor reviews · 2010Review
- Adipocytokines: The pied pipers.Journal of pharmacology & pharmacotherapeutics · 2010Article
- Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice.Journal of leukocyte biology · 2010Article
- Three questions about leptin and immunity.Brain, behavior, and immunity · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Adipokines, cytokines mainly produced by adipocytes, are active participants in the regulation of inflammation. Administration of zymosan (ZY) was used to investigate the regulation and role of adipokines during peritonitis in mice. Injection of ZY led to a significant increase in leptin levels in both serum and peritoneal lavage fluid, whereas a differential trend in local vs. systemic levels was observed for both resistin and adiponectin. The role of leptin in ZY-induced peritonitis was investigated using leptin-deficient ob/ob mice, with and without reconstitution with exogenous leptin. Leptin deficiency was associated with delayed resolution of peritoneal inflammation induced by ZY, because ob/ob mice had a more pronounced cellular infiltrate in the peritoneum as well as higher and prolonged local and systemic levels of IL-6, TNFalpha, IL-10, and chemokine (C-X-C motif) ligand 2 compared with wild-type mice. Reconstitution with exogenous leptin exacerbated the inflammatory infiltrate and systemic IL-6 levels in ob/ob mice while inhibiting production of TNFalpha, IL-10, and chemokine (C-X-C motif) ligand 2. In contrast with the important role of leptin in regulating each aspect of ZY-induced peritonitis, adiponectin deficiency was associated only with a decreased inflammatory infiltrate, without affecting cytokine levels. These findings point to a complex role for adipokines in ZY-induced peritonitis and further emphasize the interplay between obesity and inflammation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.