ArticleThe Journal of physiology2008
Interactions between multiple sources of short-term plasticity during evoked and spontaneous activity at the rat calyx of Held.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Postsynaptic frequency filters shaped by the interplay of synaptic short-term plasticity and cellular time scales.Journal of computational neuroscience · 2025Article
- Presynaptic ATP Decreases During Physiological-Like Activity in Neurons Tuned for High-Frequency Transmission.Journal of neurochemistry · 2025Article
- Short-term neuronal and synaptic plasticity act in synergy for deviance detection in spiking networks.PLoS computational biology · 2023Article
- Temporal filters in response to presynaptic spike trains: interplay of cellular, synaptic and short-term plasticity time scales.Journal of computational neuroscience · 2022Article
- Article
- Nitric Oxide Signaling in the Auditory Pathway.Frontiers in neural circuits · 2021Review
- A Slow Short-Term Depression at Purkinje to Deep Cerebellar Nuclear Neuron Synapses Supports Gain-Control and Linear Encoding over Second-Long Time Windows.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Glucose and lactate as metabolic constraints on presynaptic transmission at an excitatory synapse.The Journal of physiology · 2018Article
- Calcium channels and synaptic transmission in familial hemiplegic migraine type 1 animal models.Biophysical reviews · 2014Review
- Inhibitory glycinergic neurotransmission in the mammalian auditory brainstem upon prolonged stimulation: short-term plasticity and synaptic reliability.Frontiers in neural circuits · 2014Article
- Theoretical models of synaptic short term plasticity.Frontiers in computational neuroscience · 2013Article
- The diverse functions of short-term plasticity components in synaptic computations.Communicative & integrative biology · 2011Article
- A new kinetic framework for synaptic vesicle trafficking tested in synapsin knock-outs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Nitric oxide is an activity-dependent regulator of target neuron intrinsic excitability.Neuron · 2011Article
- The number of components of enhancement contributing to short-term synaptic plasticity at the neuromuscular synapse during patterned nerve Stimulation progressively decreases as basal release probability is increased from low to normal levels by changing extracellular Ca2+.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Going native: voltage-gated potassium channels controlling neuronal excitability.The Journal of physiology · 2010Review
- Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Sustained activity at most central synapses is accompanied by a number of short-term changes in synaptic strength which act over a range of time scales. Here we examine experimental data and develop a model of synaptic depression at the calyx of Held synaptic terminal that combines many of these mechanisms (acting at differing sites and across a range of time scales). This new model incorporates vesicle recycling, facilitation, activity-dependent vesicle retrieval and multiple mechanisms affecting calcium channel activity and release probability. It can accurately reproduce the time course of experimentally measured short-term depression across different stimulus frequencies and exhibits a slow decay in EPSC amplitude during sustained stimulation. We show that the slow decay is a consequence of vesicle release inhibition by multiple mechanisms and is accompanied by a partial recovery of the releasable vesicle pool. This prediction is supported by patch-clamp data, using long duration repetitive EPSC stimulation at up to 400 Hz. The model also explains the recovery from depression in terms of interaction between these multiple processes, which together generate a stimulus-history-dependent recovery after repetitive stimulation. Given the high rates of spontaneous activity in the auditory pathway, the model also demonstrates how these multiple interactions cause chronic synaptic depression under in vivo conditions. While the magnitude of the depression converges to the same steady state for a given frequency, the time courses of onset and recovery are faster in the presence of spontaneous activity. We conclude that interactions between multiple sources of short-term plasticity can account for the complex kinetics during high frequency stimulation and cause stimulus-history-dependent recovery at this relay synapse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.