ArticleGene therapy2008
Oxidative stress-inducible lentiviral vectors for gene therapy.
Article in Gene therapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
- Inhibition of the CEBPβ-NFκB interaction by nanocarrier-packaged Carnosic acid ameliorates glia-mediated neuroinflammation and improves cognitive function in an Alzheimer's disease model.Cell death & disease · 2022Article
- Regulation of the Expression of Heme Oxygenase-1: Signal Transduction, Gene Promoter Activation, and Beyond.Antioxidants & redox signaling · 2020Review
- Sema7A, a brain immune regulator, regulates seizure activity in PTZ-kindled epileptic rats.CNS neuroscience & therapeutics · 2020Article
- Research Progress in Understanding the Relationship Between Heme Oxygenase-1 and Intracerebral Hemorrhage.Frontiers in neurology · 2018Review
- Inhibition of NFE2L2-Antioxidant Response Element Pathway by Mitochondrial Reactive Oxygen Species Contributes to Development of Cardiomyopathy and Left Ventricular Dysfunction in Chagas Disease.Antioxidants & redox signaling · 2017Article
- Lentiviral Vector-Induced Overexpression of RGMa in the Hippocampus Suppresses Seizures and Mossy Fiber Sprouting.Molecular neurobiology · 2017Article
- The Effects of Sequence Variation on Genome-wide NRF2 Binding--New Target Genes and Regulatory SNPs.Nucleic acids research · 2016Article
- Biliary tract external drainage increases the expression levels of heme oxygenase-1 in rat livers.European journal of medical research · 2015Article
- CD36 upregulation mediated by intranasal LV-NRF2 treatment mitigates hypoxia-induced progression of Alzheimer's-like pathogenesis.Antioxidants & redox signaling · 2014Article
- Antioxidant enzymes reduce DNA damage and early activation of valvular interstitial cells in aortic valve sclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2013Article
- The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer.Redox biology · 2013Review
- HIV-1 gp120 induces antioxidant response element-mediated expression in primary astrocytes: role in HIV associated neurocognitive disorder.Neurochemistry international · 2012Article
- Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism.The Journal of biological chemistry · 2011Article
- An insult-inducible vector system activated by hypoxia and oxidative stress for neuronal gene therapy.Translational stroke research · 2011Article
- Lentiviral-human heme oxygenase targeting endothelium improved vascular function in angiotensin II animal model of hypertension.Human gene therapy · 2011Article
- Efficient transduction of cytotoxic and anti-HIV-1 genes by a gene-regulatable lentiviral vector.Virus genes · 2009Article
- Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Heme oxygenase-1/carbon monoxide: from metabolism to molecular therapy.American journal of respiratory cell and molecular biology · 2009Review
- Antioxidant enzyme gene transfer for ischemic diseases.Advanced drug delivery reviews · 2009Review
- Lentiviral vectors for gene transfer into the spinal cord glial cells.Gene therapy · 2009Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress is important in several pathologies, including cardiovascular diseases such as atherosclerosis and cardiac ischemia-reperfusion injury. An important mechanism for adaptation to oxidative stress is induction of genes through the antioxidant response element (ARE), which regulates the expression of antioxidant and cytoprotective genes via the transcription factor Nrf2 (nuclear factor E2-related factor 2). As Nrf2-regulated genes are induced during oxidant stress occurring, for example, in reperfusion after ischemia, we took a novel approach to exploit ARE for the development of oxidative stress-inducible gene therapy vectors. To this end, one, two or three ARE-containing regions from human NAD(P)H:quinone oxidoreductase-1, glutamate-cysteine ligase modifier subunit and mouse heme oxygenase-1 were cloned into a vector expressing luciferase under a minimal SV40 promoter. The construct, which was the most responsive to ARE-inducing agents, was chosen for further studies in which a lentiviral vector was produced for an efficient transfer to endothelial cells. Heme oxygenase-1 (HO-1), which has well-characterized anti-inflammatory properties, was used as the therapeutic transgene. In human endothelial cells, ARE-driven HO-1 overexpression inhibited nuclear factor-kappaB activation and subsequent vascular cell adhesion molecule-1 expression induced by tumor necrosis factor-alpha. We conclude that the ARE element is a promising alternative for the development of oxidative stress-inducible gene therapy vectors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.