ArticleThe Journal of pharmacology and experimental therapeutics2008
Influence of lipid-soluble gating modifier toxins on sodium influx in neocortical neurons.
Article in The Journal of pharmacology and experimental therapeutics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Article
- Antillatoxin-Stimulated Neurite Outgrowth Involves the Brain-Derived Neurotrophic Factor (BDNF) - Tropomyosin Related Kinase B (TrkB) Signaling Pathway.Journal of natural products · 2022Article
- Voltage-Gated Sodium Channels: A Prominent Target of Marine Toxins.Marine drugs · 2021Review
- Pagoamide A, a Cyclic Depsipeptide Isolated from a Cultured Marine Chlorophyte,Journal of natural products · 2020Article
- Biotechnological and Pharmacological Applications of Biotoxins and Other Bioactive Molecules from Dinoflagellates.Marine drugs · 2017Review
- Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons.Scientific reports · 2017Article
- Development of a Rapid Throughput Assay for Identification of hNav1.7 Antagonist Using Unique Efficacious Sodium Channel Agonist, Antillatoxin.Marine drugs · 2016Article
- Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows.PloS one · 2015Article
- Detailed analysis of (-)-palmyrolide a and some synthetic derivatives as voltage-gated sodium channel antagonists.Journal of natural products · 2014Article
- Gambierol inhibition of voltage-gated potassium channels augments spontaneous Ca2+ oscillations in cerebrocortical neurons.The Journal of pharmacology and experimental therapeutics · 2014Article
- Chemical construction and structural permutation of neurotoxic natural product, antillatoxin: importance of the three-dimensional structure of the bulky side chain.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2014Article
- A technique for quantifying intracellular free sodium ion using a microplate reader in combination with sodium-binding benzofuran isophthalate and probenecid in cultured neonatal rat cardiomyocytes.BMC research notes · 2013Article
- Shellfish toxins targeting voltage-gated sodium channels.Marine drugs · 2013Review
- Novel C-1 substituted cocaine analogs unlike cocaine or benztropine.The Journal of pharmacology and experimental therapeutics · 2012Article
- Additivity of pyrethroid actions on sodium influx in cerebrocortical neurons in primary culture.Environmental health perspectives · 2011Article
- Mechanism of pyrethroid pesticide-induced apoptosis: role of calpain and the ER stress pathway.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- Total synthesis of brevenal.Journal of the American Chemical Society · 2011Article
- Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNav1.2, rNav1.4 and rNav1.5 α subunits.BMC neuroscience · 2010Article
- Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels.The Journal of pharmacology and experimental therapeutics · 2010Article
- Hoiamide a, a sodium channel activator of unusual architecture from a consortium of two papua new Guinea cyanobacteria.Chemistry & biology · 2009Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
The electrical signals of neurons are fundamentally dependent on voltage-gated sodium channels (VGSCs), which are responsible for the rising phase of the action potential. An array of naturally occurring and synthetic neurotoxins have been identified that modify the gating properties of VGSCs. Using murine neocortical neurons in primary culture, we have compared the ability of VGSC gating modifiers to evoke Na+ influx. Intracellular sodium concentration ([Na+](i)) was monitored using the Na+-sensitive fluorescent dye, sodium-binding benzofuran isophthalate. All sodium channel gating modifier compounds tested produced a rapid and concentration-dependent elevation in neuronal [Na+](i). The increment in [Na+](i) exceeded 40 mM at high concentrations of brevetoxins, batrachotoxin, and the novel lipopeptide, antillatoxin. The maximal increments in neuronal [Na+](i) produced by neurotoxin site 2 alkaloids, veratridine and aconitine, and the pyrethroid deltamethrin were somewhat lower with maximal [Na+](i) increments of less than 40 mM. The rank order of efficacy of sodium channel gating modifiers was brevetoxin (PbTx)-1 > PbTx-desoxydioxolane > batrachotoxin > antillatoxin > PbTx-2 = PbTx-3 > PbTx-3alpha-naphthoate > veratridine > deltamethrin > aconitine > gambierol. These data demonstrate that the ability of sodium channel gating modifiers to act as partial agonists is shared by compounds acting at both neurotoxin sites 2 and 5. The concentration-dependent increases in [Na+](i) produced by PbTx-2, antillatoxin, veratridine, deltamethrin, aconitine, and gambierol were all abrogated by tetrodotoxin, indicating that VGSCs represent the sole pathway of Na+ entry after exposure to gating modifier neurotoxins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.