ArticleBiology of reproduction2008
Gastrin-releasing peptide (GRP) in the ovine uterus: regulation by interferon tau and progesterone.
Article in Biology of reproduction, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 47 citations in OpenAlex.
- Adaptive landscape and genetic divergence of Karnah sheep revealed by selection scans across multiple ovine breeds.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Spatially resolved transcriptomic profiling of placental development in dairy cow.Zoological research · 2024Article
- Extracellular Vesicles Secreted by Pre-Hatching Bovine Embryos Produced In Vitro and In Vivo Alter the Expression of IFNtau-Stimulated Genes in Bovine Endometrial Cells.International journal of molecular sciences · 2023Article
- Altrenogest Supplementation during Early Pregnancy Improves Reproductive Outcome in Pigs.Animals : an open access journal from MDPI · 2022Article
- The proteome of IVF-induced aberrant embryo-maternal crosstalk by implantation stage in ewes.Journal of animal science and biotechnology · 2020Article
- Analysis and Screening of Reproductive Long Non-coding RNAs Through Genome-Wide Analyses of Goat Endometrium During the Pre-attachment Phase.Frontiers in genetics · 2020Article
- Comparative analysis between endometrial proteomes of pregnant and non-pregnant ewes during the peri-implantation period.Journal of animal science and biotechnology · 2015Article
- Extracellular vesicles in luminal fluid of the ovine uterus.PloS one · 2014Article
- Alterations in expression of endometrial genes coding for proteins secreted into the uterine lumen during conceptus elongation in cattle.BMC genomics · 2013Article
- Article
- Select nutrients, progesterone, and interferon tau affect conceptus metabolism and development.Annals of the New York Academy of Sciences · 2012Review
- Uterine biology in pigs and sheep.Journal of animal science and biotechnology · 2012Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Gastrin-releasing peptide (GRP) is abundantly expressed by endometrial glands of the ovine uterus and processed into different bioactive peptides, including GRP1-27, GRP18-27, and a C-terminus, that affect cell proliferation and migration. However, little information is available concerning the hormonal regulation of endometrial GRP and expression of GRP receptors in the ovine endometrium and conceptus. These studies determined the effects of pregnancy, progesterone (P4), interferon tau (IFNT), placental lactogen (CSH1), and growth hormone (GH) on expression of GRP in the endometrium and GRP receptors (GRPR, NMBR, BRS3) in the endometrium, conceptus, and placenta. In pregnant ewes, GRP mRNA and protein were first detected predominantly in endometrial glands after Day 10 and were abundant from Days 18 through 120 of gestation. Treatment with IFNT and progesterone but not CSH1 or GH stimulated GRP expression in the endometrial glands. Western blot analyses identified proGRP in uterine luminal fluid and allantoic fluid from Day 80 unilateral pregnant ewes but not in uterine luminal fluid of either cyclic or early pregnant ewes. GRPR mRNA was very low in the Day 18 conceptus and undetectable in the endometrium and placenta; NMBR and BRS3 mRNAs were undetectable in ovine uteroplacental tissues. Collectively, the present studies validate GRP as a novel IFNT-stimulated gene in the glands of the ovine uterus, revealed that IFNT induction of GRP is dependent on P4, and found that exposure of the ovine uterus to P4 for 20 days induces GRP expression in endometrial glands.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.