ArticleObstetrics and gynecology2008
Lynch syndrome in women less than 50 years of age with endometrial cancer.
Article in Obstetrics and gynecology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- The proportion of endometrial cancers associated with Lynch syndrome: a systematic review of the literature and meta-analysis.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Pooled it
- Traditional and New Views on MSI-H/dMMR Endometrial Cancer.Biomolecules · 2025Review
- The Role of Immunohistochemistry Markers in Endometrial Cancer with Mismatch Repair Deficiency: A Systematic Review.Cancers · 2022Review
- Using amide proton transfer-weighted MRI to non-invasively differentiate mismatch repair deficient and proficient tumors in endometrioid endometrial adenocarcinoma.Insights into imaging · 2021Article
- Genome profiling of mismatch repair genes in eight types of tumors.Cell cycle (Georgetown, Tex.) · 2021Article
- Wise Management of Ovarian Cancer: On the Cutting Edge.Journal of personalized medicine · 2020Review
- Mismatch repair deficiency/microsatellite instability-high as a predictor for anti-PD-1/PD-L1 immunotherapy efficacy.Journal of hematology & oncology · 2019Review
- Endometrial cancer risk and survival by tumor MMR status.Journal of gynecologic oncology · 2018Article
- Molecular classification and precision therapy of cancer: immune checkpoint inhibitors.Frontiers of medicine · 2018Article
- Comparison of lifestyle, hormonal and medical factors in women with sporadic and Lynch syndrome-associated endometrial cancer: A retrospective case-case study.Molecular and clinical oncology · 2017Article
- Deficient mismatch repair: Read all about it (Review).International journal of oncology · 2015Review
- Development of an integrated support system for hereditary cancer and its impact on gynecologic services.International journal of clinical oncology · 2014Article
- Mismatch repair protein expression in 1049 endometrial carcinomas, associations with body mass index, and other clinicopathologic variables.Gynecologic oncology · 2014Article
- Role of endometrial cancer abnormal MMR protein in screening Lynch-syndrome families.International journal of clinical and experimental pathology · 2014Article
- Clinical and histomolecular endometrial tumor characterization of patients at-risk for Lynch syndrome in South of Brazil.Familial cancer · 2010Article
- Current and emerging trends in Lynch syndrome identification in women with endometrial cancer.Gynecologic oncology · 2009Review
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10 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo estimate the frequency of mismatch repair deficiencies associated with hereditary nonpolyposis colorectal cancer, or Lynch syndrome, in women less than age 50 with endometrial cancer.
methodsConsecutive patients less than age 50 diagnosed with endometrial adenocarcinoma were identified. Available pathologic specimens were freshly sliced, and protein expression for MLH1, MSH2, MSH6, and PMS2 was evaluated by immunohistochemistry. Slides were scored on a semiquantitative method with complete absence of any of the four proteins suggesting a deficiency. All results were confirmed by microsatellite instability testing.
resultsSixty-one pathology specimens were analyzed. Twenty-one (34%) of the tumors had absence of staining of at least one of the four mismatch repair proteins determined by immunohistochemistry and confirmed by microsatellite instability testing. Obese patients were less likely than nonobese patients to have a mismatch repair deficiency (21% versus 59%, respectively). Non-obese patients had a relative risk for a mismatch repair deficiency of 5.5 (95% confidence interval 1.6-19.1; P=.01).
conclusionMany women diagnosed with endometrial cancer before age 50 will have a mismatch repair deficiency discovered by immunohistochemistry and microsatellite instability testing. A number of young women diagnosed with endometrial cancer will require further genetic testing for mismatch repair mutations. LEVEL OF EVIDENCE: III.
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