ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Ca-stimulated type 8 adenylyl cyclase is required for rapid acquisition of novel spatial information and for working/episodic-like memory.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 68 citations in OpenAlex.
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- Physiological roles of mammalian transmembrane adenylyl cyclase isoforms.Physiological reviews · 2022Review
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- Protein kinase A facilitates relaxation of mouse ileum via phosphorylation of neuronal nitric oxide synthase.British journal of pharmacology · 2020Article
- Sensitive Assessment of Hippocampal Learning Using Temporally Dissociated Passive Avoidance Task.Bio-protocol · 2016Article
- Genetic Demonstration of a Role for Stathmin in Adult Hippocampal Neurogenesis, Spinogenesis, and NMDA Receptor-Dependent Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Simultaneous impairment of passive avoidance learning and nociception in rats following chronic swim stress.Advanced biomedical research · 2016Article
- A reduced susceptibility to chemoconvulsant stimulation in adenylyl cyclase 8 knockout mice.Epilepsy research · 2016Article
- Deficits in behavioral sensitization and dopaminergic responses to methamphetamine in adenylyl cyclase 1/8-deficient mice.Journal of neurochemistry · 2015Article
- Experience-Dependent Induction of Hippocampal ΔFosB Controls Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Protective effect of neovibsanin B on spatial cognitive functions of rats with cerebrovascular hypoperfusion.International journal of clinical and experimental medicine · 2015Article
- Behavioral analysis of male and female Fmr1 knockout mice on C57BL/6 background.Behavioural brain research · 2014Article
- Ezh2 regulates adult hippocampal neurogenesis and memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
Abstract
Ca-stimulated adenylyl cyclases (ACs) transduce neuronal stimulation-evoked increase in calcium to the production of cAMP, which impinges on the regulation of many aspects of neuronal function. Type 1 and type 8 AC (AC1 and AC8) are the only ACs that are directly stimulated by Ca. Although AC1 function was implicated in regulating reference spatial memory, the function of AC8 in memory formation is not known. Because of the different biochemical properties of AC1 and AC8, these two enzymes may have distinct functions. For example, AC1 activity is regulated by both Ca and G-proteins. In contrast, AC8 is a pure Ca sensor. It is neither stimulated by G(s) nor inhibited by G(i). Recent studies also suggested that AC1 and AC8 were differentially concentrated at different subcellular domains, implicating that Ca-stimulated signaling might be compartmentalized. In this study, we used AC8 knock-out (KO) mice and found behavioral deficits in memory retention for temporal dissociative passive avoidance and object recognition memory. When examined by Morris water maze, AC8 KO mice showed normal reference memory. However, the acquisition of newer spatial information was defective in AC8 KO mice. Furthermore, AC8 KO mice were severely impaired in hippocampus-dependent episodic-like memory when examined by the delayed matching-to-place task. Because AC8 is preferentially localized at the presynaptic active zone, our results suggest a novel role of presynaptic cAMP signaling in memory acquisition and retention, as well as distinct mechanisms underlying reference and working/episodic-like memory.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.