ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Long-range axonal calcium sweep induces axon retraction.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Synaptic Phospholipid Signaling Modulates Axon Outgrowth via Glutamate-dependent Ca2+-mediated Molecular Pathways.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Prostaglandin E2 facilitates subcellular translocation of the EP4 receptor in neuroectodermal NE-4C stem cells.Biochemistry and biophysics reports · 2016Article
- Functional imaging of neuron-astrocyte interactions in a compartmentalized microfluidic device.Microsystems & nanoengineering · 2016Article
- Neuraminidase-Dependent Degradation of Polysialic Acid Is Required for the Lamination of Newly Generated Neurons.PloS one · 2016Article
- Calcium signals and FGF-2 induced neurite growth in cultured parasympathetic neurons: spatial localization and mechanisms of activation.Pflugers Archiv : European journal of physiology · 2013Article
- Article
- GABAergic excitation after febrile seizures induces ectopic granule cells and adult epilepsy.Nature medicine · 2012Article
- Spatial and temporal second messenger codes for growth cone turning.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Nitric oxide synthase regulates morphogenesis of zebrafish spinal cord motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Neocortical axon arbors trade-off material and conduction delay conservation.PLoS computational biology · 2010Article
- Glutamate controls growth rate and branching of dopaminergic axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Overcoming macrophage-mediated axonal dieback following CNS injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Glutamate receptors on myelinated spinal cord axons: I. GluR6 kainate receptors.Annals of neurology · 2009Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Axon guidance molecules trigger a cascade of local signal in growth cones and evoke various morphologic responses, including axon attraction, repulsion, elongation, and retraction. However, little is known about whether subcellular compartments, other than axonal growth cones, control axon outgrowth. We found that in isolated dentate granule cells, local application of glutamate to the somatodendritic areas, but not the axon itself, induced rapid axon retraction, during which a calcium wave propagated from the somata to the axon terminals. The calcium wave and axon retraction were both inhibited by blockade of voltage-sensitive calcium channels and intracellular calcium dynamics. A combination of perisomatic application of calcium ionophore and depolarizing current injection induced axonal calcium sweep and axon retraction. Thus, perisomatic environments can modulate axon behavior through long-range intracellular communication.
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