ArticleThe Journal of biological chemistry2008
SDF-1alpha promotes invasion of head and neck squamous cell carcinoma by activating NF-kappaB.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- CXCL12 is expressed by skeletal muscle cells in tongue oral squamous cell carcinoma.Cancer medicine · 2023Article
- The Effects of Mesenchymal Stem Cells on Oral Cancer and Possible Therapy Regime.Frontiers in genetics · 2022Review
- Upregulation of Serine Proteinase Inhibitor Clade B Member 3 (SERPINB3) Expression by Stromal Cell-Derived Factor (SDF-1)/CXCR4/Nuclear Factor kappa B (NF-κB) Promotes Migration and Invasion of Gastric Cancer Cells.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- C-X-C Chemokine Receptor Type 4 Plays a Crucial Role in Mediating Oxidative Stress-Induced Podocyte Injury.Antioxidants & redox signaling · 2017Article
- Expression of the CXCL12/CXCR4 chemokine axis predicts regional control in head and neck squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- CXCL12 expression promotes esophageal squamous cell carcinoma proliferation and worsens the prognosis.BMC cancer · 2016Article
- BCL10 is recruited to sites of DNA damage to facilitate DNA double-strand break repair.Cell cycle (Georgetown, Tex.) · 2016Article
- Annexin 2-CXCL12 interactions regulate metastatic cell targeting and growth in the bone marrow.Molecular cancer research : MCR · 2015Article
- Chemokine function in periodontal disease and oral cavity cancer.Frontiers in immunology · 2015Review
- Differential expression of SDF-1 isoforms in bladder cancer.The Journal of urology · 2014Article
- Analysis of chemokine and chemokine receptor expression in squamous cell carcinoma of the head and neck (SCCHN) cell lines.Radiation and environmental biophysics · 2011Article
- Recently identified biomarkers that promote lymph node metastasis in head and neck squamous cell carcinoma.Cancers · 2011Article
- Identification of tetranectin as a potential biomarker for metastatic oral cancer.International journal of molecular sciences · 2010Article
- Integrating chemotaxis and contact-inhibition during collective cell migration: Small GTPases at work.Small GTPases · 2010Article
- EPS8 upregulates FOXM1 expression, enhancing cell growth and motility.Carcinogenesis · 2010Article
- A novel CXCR4 antagonist derived from human SDF-1beta enhances angiogenesis in ischaemic mice.Cardiovascular research · 2009Article
- An orthotopic murine model of sinonasal malignancy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
CXCL12/stromal cell-derived factor-1alpha (SDF-1alpha), a chemokine ligand for the G protein-coupled receptor CXCR4, plays an important role in the directed movement of cells. Many studies have documented the importance of CXCR4 in tumor progression and organ-specific metastasis. Recently, several studies have implicated a role for SDF-1alpha in head and neck squamous cell carcinoma (HNSCC) metastasis, but currently there is little information about how SDF-1alpha promotes HNSCC metastasis. In this report we show that the NF-kappaB signaling pathway is activated in response to SDF-1alpha in HNSCC while primary and immortalized keratinocytes show no SDF-1alpha-mediated NF-kappaB activity. We found that SDF-1alpha-mediated NF-kappaB signaling is independent of phosphoinositide 3-kinase/Akt and ERK/MAPK pathways. We observed that SDF-1alpha induces IkappaBalpha phosphorylation and degradation and the nuclear translocation of NF-kappaB in HNSCC cell lines, suggesting that SDF-1alpha activates the classical NF-kappaB signaling pathway. Contrary to previous reports, SDF-1alpha-induced NF-kappaB activation is not mediated by tumor necrosis factor alpha. Furthermore, blocking the NF-kappaB signaling pathway with an IKKbeta inhibitor significantly reduces SDF-1alpha-mediated HNSCC invasion. Taken together, our data suggest SDF-1alpha/CXCR4 may promote HNSCC invasion and metastasis by activating NF-kappaB and that targeting NF-kappaB may provide therapeutic opportunities in preventing HNSCC metastasis mediated by SDF-1alpha.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.